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human homolog plays a role in anti-apoptosis. Additionally we are shipping PTMA Antibodies (87) and PTMA Kits (28) and many more products for this protein.
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Human PTMA Protein expressed in Escherichia coli (E. coli) - ABIN2004267
Manrow, Leone, Krug, Eschenfeldt, Berger: The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. in Genomics 1992
Show all 2 references for ABIN2004267
These results demonstrate the clinical relevance of prothymosin alpha in regulating acetylation events during the pathogenesis of emphysema.
Only neurons possess the specific mechanisms required to release prothymosin-alpha following cerebral ischemic stress in vivo.
Regional distribution and cell type-specific subcellular localization of Prothymosin alpha in brain.
Thymosin alpha-1 could relieve radiation-induced acute and late pulmonary injuries.
observations suggest that Talpha1 can positively modulate the haematopoietic functions of normal murine bone marrow cells, in addition to its myelorestorative role in tumour-bearing mice showing suppressed myelopoiesis [thymosin alpha-1]
thymosin alpha 1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12 production by fungus-pulsed DCs through the p38 mitogen-activated protein kinase (show MAPK14 Proteins)/nuclear factor (NF)-kappaB (show NFKB1 Proteins)-dependent pathway.
ProT (show SLC6A7 Proteins) overexpression in the kidneys of homozygous transgenic mice induced a PKD (show PRKD1 Proteins) phenotype, which included polycystic kidneys, elevated blood urea nitrogen (BUN), and lethality at about 10 days of age.
Keap1 (show KEAP1 Proteins)-bound prothymosin alpha peptide possesses a hairpin conformation and binds to cytoplasmic repressor Keap1 (show KEAP1 Proteins) at the bottom region of the beta-propeller domain; complex formation occurs as a consequence of their complementary electrostatic interactions.
The systemic administration of Prothymosin alpha switches ischemia-induced necrosis to apoptosis, which in turn is inhibited by neurotrophic factors upregulated by Prothymosin alpha and ischemia.
prothymosin-alpha-mediated nuclear import of INrf2 (show KEAP1 Proteins)/Cul3 (show CUL3 Proteins) Rbx1 complex leads to ubiquitination and degradation of Nrf2 (show NFE2L2 Proteins) inside the nucleus presumably to regulate nuclear level of Nrf2 (show NFE2L2 Proteins) and rapidly switch off the activation of Nrf2 (show NFE2L2 Proteins) downstream gene expression.
PTMA is a potential novel therapeutic target for type 2 diabetes
disease-free survival and overall survival rates were significantly lower among colorectal cancer patients with PTMA- and TP53 (show TP53 Proteins)-positive tumors
Data suggest that KEAP1 (kelch-like ECH-associated protein 1 (show KEAP1 Proteins)) mutations (as those observed in lung cancer patients) affect conformation/folding/stability of KEAP1 (show KEAP1 Proteins) and binding affinity for ligands PTMA and NRF2 (nuclear factor erythroid 2-like 2 (show NFE2L2 Proteins)).
Data suggest that plasma thymosin-alpha1 (TA1 (show TAAR1 Proteins)) and prothymosin-alpha (PTMA) level may be a biomarker for differentiating between renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) and urothelial carcinoma.
prothymosin-alpha expression is a determinant of disease progression in superficial bladder cancer
PTalpha (show PTCRA Proteins) offers cardioprotection against ischemic injury by an Akt (show AKT1 Proteins)-dependent mechanism.
The PTMA is one of miR-1 target genes which involve in miR-1 inducing apoptosis.
Findings suggest that the binding of prothymosin alpha (ProTalpha) and Neh2 (show NEIL2 Proteins) to Keap1 (show KEAP1 Proteins) occurs synergistically via preformed structural elements.
Nuclear PTMA may serve as prognostic marker in head and neck squamous cell carcinoma to determine the subset of patients that are likely to show recurrence of the disease.
human homolog plays a role in anti-apoptosis
, prothymosin, alpha (gene sequence 28)
, prothymosin alpha
, gene sequence 28
, prothymosin alpha protein