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Proto-Oncogene Pim-2 (Serine Threonine Kinase) Proteins (PIM2)

PIM2 encodes a protooncogene that acts as a serine/threonine protein kinase. Additionally we are shipping Proto-Oncogene Pim-2 (Serine Threonine Kinase) Antibodies (97) and Proto-Oncogene Pim-2 (Serine Threonine Kinase) Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIM2 11040 Q9P1W9
PIM2 317366  
PIM2 18715 Q62070
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Top Proto-Oncogene Pim-2 (Serine Threonine Kinase) Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 5 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,827.00
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$510.36
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details

PIM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Rat (Rattus)

Mouse (Murine)
,

Top referenced Proto-Oncogene Pim-2 (Serine Threonine Kinase) Proteins

  1. Human PIM2 Protein expressed in Baculovirus infected Insect Cells - ABIN411937 : Baytel, Shalom, Madgar, Weissenberg, Don: The human Pim-2 proto-oncogene and its testicular expression. in Biochimica et biophysica acta 1998 (PubMed)
    Show all 3 references for ABIN411937

More Proteins for Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Interaction Partners

Zebrafish Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. Inhibition of the Pim1 (show PIM1 Proteins) oncogene (show RAB1A Proteins) results in diminished visual function.

Human Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. We show that Pim2 inhibitors and proteasome inhibitors, such as bortezomib, have additive effects to inhibit the growth of myeloma cells, suggesting that Pim2 could be an interesting target for the treatment of multiple myeloma.

  2. PIM2 gene knockdown enhances the anti-proliferative effect of AZD1208 in non-Hodgkin lymphoma cell line.

  3. A high percentage of urothelial carcinomas express Pim (show PIM1 Proteins) kinases. Pim (show PIM1 Proteins) expression differs in NILG, NIHG, and IHG lesions.

  4. Our findings suggest that Pim-2-mediated aerobic glycolysis is critical for monitoring Warburg effect in colorectal tumor cells, highlighting Pim-2 as a potential metabolic target for colorectal tumor therapy.

  5. our findings will help to uncover novel signaling pathways between inflammations and oxidative stress in rheumatoid arthritis development and imply that Pim-2/mTORC1 pathway may be critical for the initiation of inflammatory reactions.

  6. Persistent activation of STAT3 (show STAT3 Proteins) by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer.

  7. Data demonstrate the role of PIM (show PIM1 Proteins) kinases in driving myeloid leukemia (show BCL11A Proteins), and as candidate molecules for therapy against human malignancies.

  8. Blocking the activities of PIM (show PIM1 Proteins) kinases(PIM1 (show PIM1 Proteins), PIM2 and PIM3 (show PIM3 Proteins)) could prevent pancreatic cancer development. PIM (show PIM1 Proteins) kinases(PIM1 (show PIM1 Proteins), PIM2 and PIM3 (show PIM3 Proteins)) may be a novel target for cancer therapy

  9. HIF-1A (show HIF1A Proteins) induced PIM2 expression in HepG2 cells via binding to the hypoxia-responsive elements (HREs) of the PIM2 promoter.

  10. PIM2 could directly phosphorylate PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels. Compared with wild type, PKM2 with the phosphorylation-defective mutation displayed a reduced effect on glycolysis.

Mouse (Murine) Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) interaction partners

  1. studies define a pathway for limiting the regulation of Foxp3 (show FOXP3 Proteins) function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses

  2. Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells.

  3. Loss of PIM2 is associated with abnormal hematopoietic phenotypes.

  4. signals from IL-7 (show IL7 Proteins) and RAG DSBs activate distinct Pim (show PIM1 Proteins) kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.

  5. Targeting cap-dependent translation blocks converging survival signals by AKT (show AKT1 Proteins) and PIM 1 (show PIM1 Proteins), 2 kinases in lymphoma

  6. PIM2 controls the expression of the pro-inflammatory cytokine IL-6 (show IL6 Proteins).

  7. results support the hypothesis that Pim2, which is also a known target of Flt3 (show FLT3 Proteins)-ITD (another gene that cooperates with PML (show PML Proteins)-RARalpha (show RARA Proteins)), cooperates with PRalpha to induce acute promyelocytic leukemia (show PML Proteins)-like disease

  8. Pim-2 is a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival

  9. pim-2 functions similarly to pim-1 (show PIM1 Proteins) as a pro-survival kinase; BAD is a legitimate PIM-2 substrate

  10. Pim-2 and Akt-1 (show AKT1 Proteins) are critical components of overlapping but independent pathways, either of which is sufficient to promote the growth and survival of nontransformed hematopoietic cells

Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2) Protein Profile

Protein Summary

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.

Gene names and symbols associated with PIM2

  • pim-1 oncogene (pim1)
  • pim-2 oncogene (PIM2)
  • pim-2 oncogene (Pim2)
  • proviral integration site 2 (Pim2)
  • cb1068 protein
  • DXCch3 protein
  • fj47b05 protein
  • Pim-2 protein
  • pim2 protein
  • wu:fj47b05 protein

Protein level used designations for PIM2

kinase pim-1 , proviral integration site 2 , serine/threonine-protein kinase Pim-1 , serine/threonine-protein kinase pim-2 , pim-2h , proto-oncogene Pim-2 (serine threonine kinase) , serine/threonine protein kinase pim-2 , serine/threonine kinase

GENE ID SPECIES
58054 Danio rerio
11040 Homo sapiens
442959 Canis lupus familiaris
508424 Bos taurus
317366 Rattus norvegicus
473600 Pan troglodytes
18715 Mus musculus
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