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PCDH17 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping PCDH17 Antibodies (59) and PCDH17 Kits (1) and many more products for this protein.
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Aberrant methylation of protocadherin 17 is associated with acute lymphoblastic leukemia.
PCDH-17 inhibited metastasis via EGFR (show EGFR Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling pathway.
DNA methylation (show HELLS Proteins) in a combination of POU4F2 (show POU4F2 Proteins)/PCDH17 has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups.
PCDH17 methylation in serum is a frequent event in early-stage prostate cancer, and it is an independent predictor of BCR (show BCR Proteins) after radical prostatectomy
PCDH17 methylation occurred more frequently and was associated with malignant clinicopathological characteristics and poor prognosis in clear cell renal cell carcinoma (show MOK Proteins) patients
PCDH17 promoter methylation is closely associated with bladder cancer malignancy and may be used as an independent predictor of clinical outcomes in patients with bladder cancer.
PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer
This study demonistrated that critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors.
PCDH17 acts as a tumour suppressor, exerting its anti-proliferative activity through inducing apoptosis and autophagy, and is frequently silenced in gastric and colorectal cancers.
Our study clearly demonstrates that PCDH17 is transcriptionally downregulated in gastric cancer due to aberrant promoter CpG island methylation
Pcdh17 recruits the WAVE complex, Lamellipodin, and Ena/VASP (show VASP Proteins) to cell-cell contacts, converting these sites into motile structures.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.