Protocadherin 8 Proteins (PCDH8)

PCDH8 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping Protocadherin 8 Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCDH8 5100 O95206
PCDH8 18530 Q7TSK3
PCDH8 64865 D3ZE55
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Top Protocadherin 8 Proteins at

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

PCDH8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
Rat (Rattus)

More Proteins for Protocadherin 8 (PCDH8) Interaction Partners

Xenopus laevis Protocadherin 8 (PCDH8) interaction partners

  1. The transcription factor Snail1 (show SNAI1 Proteins) is essential for tissue separation, enabling paraxial protocadherin (PAPC) to promote tissue separation through novel functions.

  2. Because PAPC and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.

  3. Data show that PAPC signaling via RhoA (show RHOA Proteins) and Wnt5a (show WNT5A Proteins)/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.

  4. Transcriptional regulation of XPAPC by XWnt-5A (show WNT5A Proteins) requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).

  5. ShcA (show SHC1 Proteins) is required for Wnt-5a (show WNT5A Proteins)/Ror2 (show ROR2 Proteins) mediated upregulation of xPAPC, which demonstrates the functional relevance of this interaction.

Human Protocadherin 8 (PCDH8) interaction partners

  1. PCDH8 methylation may be associated with tumor progression and poor prognosis in non-muscle invasive bladder cancer.

  2. PCDH8 methylation may be a useful biomarker to predict the progression of clear cell renal cell carcinoma (show MOK Proteins).

  3. Loss of the PCDH8 gene is one of the probable causes of psychomotor delay in RB1 (show RB1 Proteins)-deleted patients.

  4. study demonstrates the epigenetic inactivation of PCDH8 by promoter methylation and its tumor suppressor function in gastric cancer

  5. These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded.

  6. Loss of PCDH8 promotes oncogenesis in epithelial human cancers by disrupting cell-cell communication dedicated to tissue organization and repression of mitogenic signaling.

Mouse (Murine) Protocadherin 8 (PCDH8) interaction partners

  1. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM (show SH2B1 Proteins) and exhibits a striking complementary pattern to N-cadherin (show CDH2 Proteins)

  2. miR (show MLXIP Proteins)-429 suppresses the expression of Pcdh8 mRNA and protein.

Protocadherin 8 (PCDH8) Protein Profile

Protein Summary

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.

Gene names and symbols associated with Protocadherin 8 Proteins (PCDH8)

  • protocadherin 8 (PCDH8)
  • protocadherin 8 (pcdh8)
  • protocadherin 8 (Pcdh8)
  • 1700080P15Rik protein
  • Arcadlin protein
  • Papc protein
  • protocadherin-8 protein
  • xpapc protein

Protein level used designations for Protocadherin 8 Proteins (PCDH8)

paraxial protocadherin , paraxial protocadherin 8 short isoform , protocadherin-8 , arcadlin , activity-regulated cadherin-like protein

452748 Pan troglodytes
444663 Xenopus laevis
428065 Gallus gallus
5100 Homo sapiens
485469 Canis lupus familiaris
513346 Bos taurus
18530 Mus musculus
64865 Rattus norvegicus
100155738 Sus scrofa
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