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PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. Additionally we are shipping Protocadherin alpha 4 Antibodies (32) and Protocadherin alpha 4 Kits (7) and many more products for this protein.
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CNR1 (show CNR1 Proteins) has a heterophilic, calcium-dependent cell adhesion activity with the beta1 integrin subfamily, suggesting the possibility of CNR (show PCDHA6 Proteins)-beta1 integrin association in synaptogenesis.
This pattern of Pcdha4 expression suggests its involvement in the development of neocortical connectivity.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
cadherin-related neuronal receptor 1
, KIAA0345-like 10
, ortholog of mouse CNR1
, protocadherin alpha-4
, cadherin-related neuronal receptor 4
, protocadherin alpha 4
, protocadherin alpha 7