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PUM1 encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. Additionally we are shipping Pumilio Homolog 1 (Drosophila) Proteins (3) and many more products for this protein.
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Human Polyclonal PUM1 Primary Antibody for GS, IP - ABIN151726
Chiu, Witkowska, Hall, Santiago, Soros, Esnault, Heidmann, Greene: High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 5 Pubmed References
Data indicate a role for RNA-binding protein Pum1 in early embryonic development.
The RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 (show ATXN1 Antibodies) but also plays an unexpectedly important role in neuronal function. Loss of Pum1 caused progressive motor dysfunction and SCA1 (show ATXN1 Antibodies)-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 (show ATXN1 Antibodies) levels.
Key components of the p53 (show TP53 Antibodies) pathway are coordinately regulated by Pumilio 1 at the posttranscriptional level, which may exemplify an RNA operon.
In (show NME1 Antibodies)mice, puf-A expression was detected primarily in retinal ganglion and pigmented cells.
A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 (show PUM2 Antibodies) and PUM1.
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 (show FOXP1 Antibodies) in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
Pumilios (including PUM1 and PUM2 (show PUM2 Antibodies)) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (show MYOD1 Antibodies) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2 (show PUM2 Antibodies).Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6.
The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs.
MED15 (show MED15 Antibodies) and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 (show ATXN1 Antibodies) protein misfolding and proteotoxicity in vitro and in vivo.
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed.
Pumilio-1 (PUM1) is a ubiquitously expressed RBP (show RBP4 Antibodies) that was shown to interact with p27 (show PAK2 Antibodies)-3' UTR (show UTS2R Antibodies).
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.
pumilio homolog 1
, pumilio homolog 1 (Drosophila)
, pumilio 1