Pumilio Homolog 1 (Drosophila) (PUM1) ELISA Kits

PUM1 encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. Additionally we are shipping Pumilio Homolog 1 (Drosophila) Antibodies (61) and Pumilio Homolog 1 (Drosophila) Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse PUM1 PUM1 80912 Q80U78
Anti-Rat PUM1 PUM1 362609  
Anti-Human PUM1 PUM1 9698 Q14671
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More ELISA Kits for Pumilio Homolog 1 (Drosophila) Interaction Partners

Mouse (Murine) Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. Data indicate a role for RNA-binding protein Pum1 in early embryonic development.

  2. The RNA-binding protein PUMILIO1 (PUM1) not only directly regulates ATAXIN1 (show ATXN1 ELISA Kits) but also plays an unexpectedly important role in neuronal function. Loss of Pum1 caused progressive motor dysfunction and SCA1 (show ATXN1 ELISA Kits)-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 (show ATXN1 ELISA Kits) levels.

  3. Key components of the p53 (show TP53 ELISA Kits) pathway are coordinately regulated by Pumilio 1 at the posttranscriptional level, which may exemplify an RNA operon.

  4. In (show NME1 ELISA Kits)mice, puf-A expression was detected primarily in retinal ganglion and pigmented cells.

Human Pumilio Homolog 1 (Drosophila) (PUM1) interaction partners

  1. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.

  2. results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1/2 and FOXP1 (show FOXP1 ELISA Kits) in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.

  3. Pumilios (including PUM1 and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]

  4. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 and PUM2.Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.

  5. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6.

  6. The promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs.

  7. MED15 (show MED15 ELISA Kits) and PUM1 proteins with coiled-coil domains are potent enhancers of polyQ-mediated ataxin-1 (show ATXN1 ELISA Kits) protein misfolding and proteotoxicity in vitro and in vivo.

  8. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)

  9. Three distinct modes of target RNA binding by PUM1 around the fifth mRNA base were observed.

  10. Pumilio-1 (PUM1) is a ubiquitously expressed RBP (show RBP4 ELISA Kits) that was shown to interact with p27 (show PAK2 ELISA Kits)-3' UTR (show UTS2R ELISA Kits).

Pumilio Homolog 1 (Drosophila) (PUM1) Antigen Profile

Antigen Summary

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with PUM1

  • pumilio homolog 1 (Drosophila) (pum1) antibody
  • pumilio homolog 1 (Drosophila) (PUM1) antibody
  • pumilio 1 (Drosophila) (Pum1) antibody
  • pumilio homolog 1 (Drosophila) (Pum1) antibody
  • pumilio RNA-binding family member 1 (PUM1) antibody
  • AA517475 antibody
  • DKFZp459K0627 antibody
  • fb96a03 antibody
  • HSPUM antibody
  • mKIAA0099 antibody
  • PUM1 antibody
  • PUMH antibody
  • PUMH1 antibody
  • pumilio1 antibody
  • PUML1 antibody
  • Pumm antibody
  • si:ch211-285e16.1 antibody
  • wu:fb96a03 antibody
  • wu:fb96a08 antibody
  • zgc:63671 antibody

Protein level used designations for PUM1

pumilio homolog 1 , pumilio homolog 1 (Drosophila) , pumilio-1 , pumilio 1

GENE ID SPECIES
394176 Danio rerio
100174674 Pongo abelii
100135847 Oncorhynchus mykiss
80912 Mus musculus
419554 Gallus gallus
362609 Rattus norvegicus
9698 Homo sapiens
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