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Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Additionally we are shipping PUM2 Proteins (4) and many more products for this protein.
Showing 10 out of 111 products:
Human Polyclonal PUM2 Primary Antibody for IP, WB - ABIN151851
Masutomi, Possemato, Wong, Currier, Tothova, Manola, Ganesan, Lansdorp, Collins, Hahn: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 6 references for ABIN151851
Human Polyclonal PUM2 Primary Antibody for EIA, FACS - ABIN360017
Kusz, Ginter-Matuszewska, Ziolkowska, Spik, Bierla, Jedrzejczak, Latos-Bielenska, Pawelczyk, Jaruzelska: Polymorphisms of the human PUMILIO2 gene and male sterility. in Molecular reproduction and development 2007
Show all 3 references for ABIN360017
Human Polyclonal PUM2 Primary Antibody for ELISA, WB - ABIN250404
Szakmary, Cox, Wang, Lin: Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. in Current biology : CB 2005
Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges
PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.
P2P-R (show RBBP6 Antibodies) expression may be translationally regulated by PUM2
Data show that Pumilio-2 is expressed most abundantly in germ cells with the highest expression in undifferentiated gonocytes and spermatogonia.
1.6A resolution X-ray crystal structure of the Puf (show NME1 Antibodies) domain from murine Pum2 was presented.
Pumilios (including PUM1 (show PUM1 Antibodies) and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (show MYOD1 Antibodies) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 (show PUM1 Antibodies) and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation.
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
Mammalian PUM2-Ago-eEF1A (show EEF1A1 Antibodies) inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.
NANOS1 (show NANOS1 Antibodies)-PUMILIO2 complex, together with GEMIN3 (show DDX20 Antibodies) and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
in mitosis, PUM2 physically associates with Aurora-A (show AURKA Antibodies) to ensure enough active Aurora-A (show AURKA Antibodies) at centrosomes for mitotic entry
Three distinct modes of target RNA binding by PUM2 around the fifth mRNA base were observed.
PUM2 as a component of conserved cellular machinery that may be required for germ cell development.
PUM2 and DAZL (show DAZL Antibodies), are capable of binding the same mRNA sequences in the 3'UTR (show UTS2R Antibodies) of human SDAD1 (show SDAD1 Antibodies) mRNA.
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
, pumilio homolog 2
, pumilio 2