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anti-Pumilio Homolog 2 (Drosophila) (PUM2) Antibodies

Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Additionally we are shipping PUM2 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PUM2 80913 Q80U58
PUM2 298874  
PUM2 23369 Q8TB72
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Top anti-PUM2 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185369 (1µg/ml) staining of Human Epstein-Barr virus immortilised lymphoblastoid lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PUM2 (arrow) using PUM2 Antibody (S182) (ABIN392131). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PUM2 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with PUM2 Antibody (S182), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PUM2 (arrow) using rabbit polyclonal PUM2 Antibody (N-term) (ABIN391821). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PUM2 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human testis tissue reacted with PUM2 Antibody (C-term) (ABIN391821), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Chimpanzee Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$720.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details

PUM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PUM2 Antibodies

  1. Human Polyclonal PUM2 Primary Antibody for EIA, FACS - ABIN360017 : Kusz, Ginter-Matuszewska, Ziolkowska, Spik, Bierla, Jedrzejczak, Latos-Bielenska, Pawelczyk, Jaruzelska: Polymorphisms of the human PUMILIO2 gene and male sterility. in Molecular reproduction and development 2007 (PubMed)
    Show all 3 references for ABIN360017

  2. Human Polyclonal PUM2 Primary Antibody for ELISA, WB - ABIN185369 : Szakmary, Cox, Wang, Lin: Regulatory relationship among piwi, pumilio, and bag-of-marbles in Drosophila germline stem cell self-renewal and differentiation. in Current biology : CB 2005 (PubMed)

More Antibodies against PUM2 Interaction Partners

Mouse (Murine) Pumilio Homolog 2 (Drosophila) (PUM2) interaction partners

  1. Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges

  2. PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.

  3. P2P-R (show RBBP6 Antibodies) expression may be translationally regulated by PUM2

  4. Data show that Pumilio-2 is expressed most abundantly in germ cells with the highest expression in undifferentiated gonocytes and spermatogonia.

  5. 1.6A resolution X-ray crystal structure of the Puf (show NME1 Antibodies) domain from murine Pum2 was presented.

Human Pumilio Homolog 2 (Drosophila) (PUM2) interaction partners

  1. Pumilios (including PUM1 (show PUM1 Antibodies) and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]

  2. Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (show MYOD1 Antibodies) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 (show PUM1 Antibodies) and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.

  3. PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation.

  4. human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)

  5. Mammalian PUM2-Ago-eEF1A (show EEF1A1 Antibodies) inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.

  6. NANOS1 (show NANOS1 Antibodies)-PUMILIO2 complex, together with GEMIN3 (show DDX20 Antibodies) and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.

  7. in mitosis, PUM2 physically associates with Aurora-A (show AURKA Antibodies) to ensure enough active Aurora-A (show AURKA Antibodies) at centrosomes for mitotic entry

  8. Three distinct modes of target RNA binding by PUM2 around the fifth mRNA base were observed.

  9. PUM2 as a component of conserved cellular machinery that may be required for germ cell development.

  10. PUM2 and DAZL (show DAZL Antibodies), are capable of binding the same mRNA sequences in the 3'UTR (show UTS2R Antibodies) of human SDAD1 (show SDAD1 Antibodies) mRNA.

PUM2 Antigen Profile

Protein Summary

Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).

Gene names and symbols associated with PUM2

  • pumilio-2 (pum-2) antibody
  • pumilio 2 (Drosophila) (Pum2) antibody
  • pumilio homolog 2 (Drosophila) (PUM2) antibody
  • pumilio homolog 2 (Drosophila) (Pum2) antibody
  • pumilio RNA-binding family member 2 (PUM2) antibody
  • 5730503J23Rik antibody
  • mKIAA0235 antibody
  • pum-2 antibody
  • PUMH2 antibody
  • PUML2 antibody
  • Pumm2 antibody

Protein level used designations for PUM2

pumilio-2 , PUM1 , pumilio homolog 2 , pumilio 2

GENE ID SPECIES
100135851 Oncorhynchus mykiss
80913 Mus musculus
421961 Gallus gallus
607618 Canis lupus familiaris
298874 Rattus norvegicus
540170 Bos taurus
23369 Homo sapiens
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