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Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Additionally we are shipping PUM2 Antibodies (112) and many more products for this protein.
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Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges
PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.
P2P-R (show RBBP6 Proteins) expression may be translationally regulated by PUM2
Data show that Pumilio-2 is expressed most abundantly in germ cells with the highest expression in undifferentiated gonocytes and spermatogonia.
1.6A resolution X-ray crystal structure of the Puf (show NME1 Proteins) domain from murine Pum2 was presented.
Pumilios (including PUM1 (show PUM1 Proteins) and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (show MYOD1 Proteins) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 (show PUM1 Proteins) and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation.
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
Mammalian PUM2-Ago-eEF1A (show EEF1A1 Proteins) inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.
NANOS1 (show NANOS1 Proteins)-PUMILIO2 complex, together with GEMIN3 (show DDX20 Proteins) and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
in mitosis, PUM2 physically associates with Aurora-A (show AURKA Proteins) to ensure enough active Aurora-A (show AURKA Proteins) at centrosomes for mitotic entry
Three distinct modes of target RNA binding by PUM2 around the fifth mRNA base were observed.
PUM2 as a component of conserved cellular machinery that may be required for germ cell development.
PUM2 and DAZL (show DAZL Proteins), are capable of binding the same mRNA sequences in the 3'UTR of human SDAD1 (show SDAD1 Proteins) mRNA.
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
, pumilio homolog 2
, pumilio 2