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The product of P2RX7 belongs to the family of purinoceptors for ATP. Additionally we are shipping P2RX7 Kits (13) and P2RX7 Proteins (8) and many more products for this protein.
Showing 10 out of 122 products:
Human Polyclonal P2RX7 Primary Antibody for IHC (p), WB - ABIN651861
Kim, Jiang, Wilson, North, Surprenant: Proteomic and functional evidence for a P2X7 receptor signalling complex. in The EMBO journal 2001
Show all 2 references for ABIN651861
Human Polyclonal P2RX7 Primary Antibody for IHC (p), IHC - ABIN451826
Tomasinsig, Pizzirani, Skerlavaj, Pellegatti, Gulinelli, Tossi, Di Virgilio, Zanetti: The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner. in The Journal of biological chemistry 2008
Dog (Canine) Polyclonal P2RX7 Primary Antibody for WB - ABIN2776151
Al-Shukaili, Al-Kaabi, Hassan: A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls. in Inflammation 2008
Cow (Bovine) Polyclonal P2RX7 Primary Antibody for IHC, WB - ABIN2776335
Buell, Talabot, Gos, Lorenz, Lai, Morris, Antonarakis: Gene structure and chromosomal localization of the human P2X7 receptor. in Receptors & channels 1999
Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 Antibodies)-dependent pathways in a zebrafish model of polycystic kidney disease.
The P2X7R rs3751142 genetic variants was not implicated in the development of gout in the male Korean population. However, we found that in a pair-wise comparison of the CA/TT P2X7R and CARD8 (show CARD8 Antibodies) genotype combination was shown to have an increased trend for the risk of gout.
Five gene polymorphisms, -762C>T (rs2393799), 946G>A (rs28360457), 1513A>C (rs3751143), 1068G>A (rs1718119), and 1096C>G (rs2230911), were selected. Our results suggest that 3 of the 5 polymorphisms of P2RX7 described above (1513A>C, 946G>A, and 1068G>A) are significantly associated with Hepatocellular Carcinoma susceptibility in a Chinese Han population.
a local Ca(2 (show CA2 Antibodies)+) signal near a fragment that encodes the intracellular P2X2R C-terminus tail is sufficient to trigger blebbing
Overexpression of P2RX7 is associated with uveal melanoma.
there is a relationship between the elevated expression of P2X3 (show P2RX3 Antibodies) receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.
a pivotal role of P2X7 receptor-pannexin-1 (show PANX1 Antibodies) in oxysterols toxicity in retinal cells
significant upregulation of P2X7R and increased IL-1beta (show IL1B Antibodies) release seems to be a particular phenomenon in patients with neuropathic pain
We identified potential nuclear and membrane biomarkers (increased expression of ZO-1 (show TJP1 Antibodies), caveolin-1 (show CAV1 Antibodies) and P2X7 receptor) of risks for placenta and pregnancy
The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture
these data indicate that activation of EGFR (show EGFR Antibodies) enhanced the expression of P2X7R in neuroblastoma (show ARHGEF16 Antibodies) cells lacking trophic support, being PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/PKC (show PRRT2 Antibodies) signaling pathway and Sp1 (show PSG1 Antibodies) mediating this pro-survival outcome
For the inflammasome-dependent IL-1beta (show IL1B Antibodies) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B Antibodies) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.
P2X7R stimulation in macrophages is able to release potent anti-inflammatory proteins, such as Annexin A1 (show ANXA1 Antibodies), independently of their polarization state suggesting for first time a potential role for P2X7R during resolution of the inflammation and not linked to the release of pro-inflammatory cytokines.
These results indicate that activation of Panx1 (show PANX1 Antibodies) and P2X7 R are required for apoptotic osteocytes in fatigued bone to trigger RANKL (show TNFSF11 Antibodies) production in neighboring bystander osteocytes and implicate ATP as an essential signal mediating this process.
A role for post-transcriptional regulation of the P2X7R in epilepsy
We also demonstrate extracellular ATP participates in regulation of inflammatory responses of colitis, through P2 x 7 receptor and inflammasome and NFkappaB signaling.
we reveal that neuronal vulnerability to ATP depends on the expression level of P2X7R
Activation of P2X7 by ATP induced the release of TNFalpha (show TNF Antibodies) from microglia which protected neurons from NMDA-induced excitotoxicity, might also account for neuroprotective properties of valproic acid
Data provide mechanistic insights into the role of KHG26792 in the inhibition of TNF-alpha (show TNF Antibodies) produced via purinergic receptor P2X7 receptor-mediated activation of NFAT (show NFATC1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways in adenosine triphosphate-treated BV-2 cells.
Results suggest that P2X7R is an important activator of the immune response that leads to type 1 diabetes.
P2X7R plays a role in the neuroinflammation in a model of mania.
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (P2X7R) and plays a role in lymphoid neoplasm metastasis.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
P2X purinoceptor 7
, purinergic receptor P2X, ligand-gated ion channel, 7
, p2X purinoceptor 7-like
, ATP receptor
, P2X7 receptor
, P2Z receptor
, purinergic receptor P2X7 variant A
, P2X7 purinoceptor
, purinergic receptor P2X7