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Purinergic Receptor P2Y, G-Protein Coupled, 1 Proteins (P2RY1)

The product of P2RY1 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY1 Antibodies (94) and P2RY1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P2RY1 18441 P49650
P2RY1 5028 P47900
P2RY1 25265 P49651
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Top P2RY1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Escherichia coli (E. coli) Cat Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

P2RY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

More Proteins for Purinergic Receptor P2Y, G-Protein Coupled, 1 (P2RY1) Interaction Partners

Mouse (Murine) Purinergic Receptor P2Y, G-Protein Coupled, 1 (P2RY1) interaction partners

  1. In P2Y1R (-/-) mice, the expression of P2Y2 (show P2RY2 Proteins) receptor in muscle was reduced by over 50 %, as compared to P2Y1R (+/+) mice. P2Y1 receptor regulated the neuromuscular junction gene expression.

  2. Our current results suggest that P2Y1 modulates heat responsiveness and chemosensation in muscle afferents to play a key role in the development of pain-related behaviors during ischemia.

  3. Provide evidence for purinergic glio-endothelial coupling during neuronal activity, highlighting the role of ATP-mediated activation of eNOS (show NOS3 Proteins) via P2Y1 receptors in functional hyperemia.

  4. P2Y1 couples to and activates TRPV4 (show TRPV4 Proteins). PKC inhibitors prevented P2Y1 receptor activation of TRPV4 (show TRPV4 Proteins).

  5. The analysis of single and double KO mice demonstrated that NTPDase2 (show ENTPD2 Proteins) and P2Y1 receptors are not required for murine eye formation

  6. Data indicate that knock down of purinergic P2Y1 receptors inhibited directed migration in neurospheres.

  7. In a mouse model of Alzheimer disease, astroglial network dysfunction is mediated by P2Y1 receptor signalling in reactive astrocytes.

  8. RhoA (show RHOA Proteins) signaling downstream of platelet P2Y, but not P2Y, represents a clear dichotomy in platelet activation during allergic inflammation versus hemostasis.

  9. purines activate SK currents via mainly P2Y1 receptors in PDGFRalpha(+) cells

  10. It involves in LPS (show TLR4 Proteins)-induced IL-6 (show IL6 Proteins) production in Kupffer cells, leading to the liver inflammation.

Guinea Pig Purinergic Receptor P2Y, G-Protein Coupled, 1 (P2RY1) interaction partners

Human Purinergic Receptor P2Y, G-Protein Coupled, 1 (P2RY1) interaction partners

  1. Synergistic inhibition of both P2Y1 and P2Y12 (show P2RY12 Proteins) adenosine diphosphate receptors by GLS (show GLS Proteins)-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.

  2. P2Y1 couples to and activates TRPV4 (show TRPV4 Proteins). PKC (show PRRT2 Proteins) inhibitors prevented P2Y1 receptor activation of TRPV4 (show TRPV4 Proteins).

  3. P2Y1 receptors are a potential pharmacological target leading smooth muscle relaxation to treat spasticity in colonic motor disorders.

  4. Data indicate that ATP-evoked Hoechst 33258 uptake was dependent on activation of P2Y receptors P2Y1 and P2Y2 (show P2RY2 Proteins).

  5. These studies demonstrate a role for P2Y receptor activation in stimulation of ATP release.

  6. The immunohistochemical results were reflected in the immunoblotting data P2RY1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.

  7. P2Y1 and P2Y12 (show P2RY12 Proteins) genes were polymorphic in a Korean population; 3 intronic P2Y12 (show P2RY12 Proteins) polymorphisms (i-139C>T, i-744T>C, i-801insA) were in complete linkage disequilibrium but not with the c.52C>T polymorphism; platelet aggregation in response to ADP associated with c.52C>T polymorphism but not with the 3 intronic polymorphisms or the P2Y1 c.1622A>T polymorphism

  8. We think that allele G provides a protective effect in events of ventilatory stress. Moreover, the significant lack of P2Y1 G allele homozygotes in the SIDS (show IDS Proteins) group shows that respiratory response plays an important role in the etiology of SIDS (show IDS Proteins)

  9. The physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1-P2Y11 receptor interaction.

  10. Low ATP concentrations potentiated epinephrine-induced platelet aggregation that was abolished by P2Y1 antagonist MRS2500 suggesting P2Y1 receptor activation due to contaminating ADP.

Cow (Bovine) Purinergic Receptor P2Y, G-Protein Coupled, 1 (P2RY1) interaction partners

  1. P2Y1 receptor-mediated responses involve Flt3 (show FLT3 Proteins) transactivation, and may identify a unique mechanism whereby cancer chemotherapy with receptor tyrosine kinase (show RET Proteins) inhibitors promotes vascular dysfunction.

  2. Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 (show PTGS2 Proteins) expression in intestinal subepithelial myofibroblasts.

  3. P2Y1 and P2Y13 receptors play a major role in vasa (show DDX4 Proteins) vasorum endothelial cells growth responses.

P2RY1 Protein Profile

Protein Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

Gene names and symbols associated with P2RY1

  • purinergic receptor P2Y, G-protein coupled 1 (P2ry1)
  • purinergic receptor P2Y, G-protein coupled, 1 (P2RY1)
  • purinergic receptor P2Y, G-protein coupled, 1 (P2ry1)
  • P2y protein
  • P2y1 protein

Protein level used designations for P2RY1

ATP receptor , P2Y purinoceptor 1 , P2Y1 receptor , P2Y1 purinoceptor , P2 purinoceptor subtype Y1 , platelet ADP receptor , P2 purinoreceptor subclass 2Y , P2Y ATP receptor 1 , ATP receptor P2Y1 , G protein-coupled receptor , P2Y1 , p2y1 purinoceptor

GENE ID SPECIES
18441 Mus musculus
100135592 Cavia porcellus
5028 Homo sapiens
25265 Rattus norvegicus
449621 Canis lupus familiaris
396275 Gallus gallus
281963 Bos taurus
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