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The product of P2RY13 belongs to the family of G-protein coupled receptors.
The P2Y13 receptor protects against atherosclerosis, primarily through its role in hepatobiliary reverse cholesterol transport
P2Y13 receptor activation is crucial in mediating the high-fat-diet and palmitic acid-induced myenteric neuronal loss.
Up-regulation of HDL (show HSD11B1 Antibodies)-cholesterol metabolism via activation of the P2Y13R using agonists could promote reverse cholesterol transport and promote inhibition of atherosclerosis progression in mice.
Findings indicate that the P2Y13 R plays an important role in the balance of osteoblast and adipocyte terminal differentiation of bone marrow progenitors.
P2Y13 receptor regulates phosphate metabolism and FGF-23 (show FGF23 Antibodies) secretion with effects on skeletal development
The regulation of P2Y13-R expression and provided evidence that P2Y13-R is tightly regulated by constitutive ubiquitination in the ER, and subsequent proteasome degradation.
The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.
results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor (show P2RX4 Antibodies) that regulates cAMP levels through adenylate cyclase 5 (show ADCY5 Antibodies) and modulates axonal elongation triggered by neurotropic factors and the PI3K-Akt (show AKT1 Antibodies)-GSK3 (show GSK3b Antibodies) pathway
P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases.
study to examine the role of P2Y13 receptor in bone homeostasis both in vivo and in vitro; deletion of the P2Y13 receptor leads to less trabecular bone in mice, by affecting both osteoblasts and osteoclasts
results demonstrate a crosstalk between two metabotropic and one ionotropic purinergic receptor (show P2RX4 Antibodies) that regulates cAMP levels through adenylate cyclase 5 (show ADCY5 Antibodies) and modulates axonal elongation triggered by neurotropic factors and the PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies)-GSK3 (show GSK3b Antibodies) pathway
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP.
G protein-coupled receptor 68
, G protein-coupled receptor 86
, G-protein coupled receptor 86
, P2Y purinoceptor 13
, Vpurinergic receptor P2Y, G-protein coupled 13
, purinergic receptor P2Y13
, G-protein coupled receptor 94