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The product of P2RX3 belongs to the family of purinoceptors for ATP. Additionally we are shipping Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins (6) and many more products for this protein.
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Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (show P2RX2 Antibodies) and P2X3 subunits
Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.
The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2 (show P2RX2 Antibodies), P2X3 and P2X7 (show P2RX7 Antibodies) receptors in the different histological layers of the human urinary bladder.
sensory proteins P2X3 and TRPV1 (show TRPV1 Antibodies) are in correlation with urothelial differentiation, while P2X5 (show P2RX5 Antibodies) and TRPV4 (show TRPV4 Antibodies) have unique expression patterns
esophagitis increases mRNA expressions of P2X3 and P2X7 (show P2RX7 Antibodies) receptors accompanied by up-regulation of TRPV1 (show TRPV1 Antibodies) and neurotrophic factors (NGF (show NGFB Antibodies) and GDNF (show GDNF Antibodies)).
Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening
TRPV1 (show TRPV1 Antibodies)-, TRPV2 (show TRPV2 Antibodies)-, P2X3-, and parvalbumin (show PVALB Antibodies)-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve
ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis.
Data indicate that MgATP2- activates P2X1 (show P2RX1 Antibodies) and P2X3, but not P2X2 (show P2RX2 Antibodies) and P2X4 (show P2RX4 Antibodies) receptors.
An early and broad expression of P2X3 receptors was found in prenatal dorsal root ganglion neurons.
mouse trigeminal neurons endogenous BNP (show BNC2 Antibodies) acts on NPR-A (show NPR1 Antibodies) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP (show BNC2 Antibodies)/NPR-A (show NPR1 Antibodies)/PKG (show PRKG1 Antibodies) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (show P2RX2 Antibodies)/P2X3 knockout mice.
a slow modulatory action by BNP (show BNC2 Antibodies) on TRPV1 (show TRPV1 Antibodies) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin
genetic manipulation of TRPV1 (show TRPV1 Antibodies) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.
up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (show CALCA Antibodies) and BDNF (show BDNF Antibodies) levels
Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]
interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.
An interaction between P2X3 and membrane-associated ERalpha (show ESR1 Antibodies) in primary sensory neurones that may represent a novel mechanism to explain sex differences observed in the clinical presentation of visceral nociceptive syndromes.
Transcripts for P2X3 were present in nearly all colon neurons examined. About half of the cells only containing P2X3 transcripts, and zymosan did not change this. The fast current triggered by ATP and alpha,beta-meATP is dependent on P2X3 receptors.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
purinergic receptor P2X, ligand-gated ion channel, 3
, P2X3 purinoceptor
, purinergic receptor P2X3
, ATP receptor
, P2X purinoceptor 3
, P2X receptor, subunit 3
, purinoceptor P2X3