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The product of P2RX3 belongs to the family of purinoceptors for ATP. Additionally we are shipping Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Antibodies (66) and Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins (6) and many more products for this protein.
Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) therapy.
Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (show P2RX2 ELISA Kits) and P2X3 subunits
Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.
The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2 (show P2RX2 ELISA Kits), P2X3 and P2X7 (show P2RX7 ELISA Kits) receptors in the different histological layers of the human urinary bladder.
sensory proteins P2X3 and TRPV1 (show TRPV1 ELISA Kits) are in correlation with urothelial differentiation, while P2X5 (show P2RX5 ELISA Kits) and TRPV4 (show TRPV4 ELISA Kits) have unique expression patterns
esophagitis increases mRNA expressions of P2X3 and P2X7 (show P2RX7 ELISA Kits) receptors accompanied by up-regulation of TRPV1 (show TRPV1 ELISA Kits) and neurotrophic factors (NGF (show NGFB ELISA Kits) and GDNF (show GDNF ELISA Kits)).
Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening
TRPV1 (show TRPV1 ELISA Kits)-, TRPV2 (show TRPV2 ELISA Kits)-, P2X3-, and parvalbumin (show PVALB ELISA Kits)-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve
ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis.
Data indicate that MgATP2- activates P2X1 (show P2RX1 ELISA Kits) and P2X3, but not P2X2 (show P2RX2 ELISA Kits) and P2X4 (show P2RX4 ELISA Kits) receptors.
mouse trigeminal neurons endogenous BNP acts on NPR-A (show NPR1 ELISA Kits) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A (show NPR1 ELISA Kits)/PKG (show PRKG1 ELISA Kits) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (show P2RX2 ELISA Kits)/P2X3 knockout mice.
a slow modulatory action by BNP on TRPV1 (show TRPV1 ELISA Kits) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin
genetic manipulation of TRPV1 (show TRPV1 ELISA Kits) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.
up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (show CALCA ELISA Kits) and BDNF (show BDNF ELISA Kits) levels
Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]
interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.
An interaction between P2X3 and membrane-associated ERalpha (show ESR1 ELISA Kits) in primary sensory neurones that may represent a novel mechanism to explain sex differences observed in the clinical presentation of visceral nociceptive syndromes.
Transcripts for P2X3 were present in nearly all colon neurons examined. About half of the cells only containing P2X3 transcripts, and zymosan did not change this. The fast current triggered by ATP and alpha,beta-meATP is dependent on P2X3 receptors.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
purinergic receptor P2X, ligand-gated ion channel, 3
, P2X3 purinoceptor
, purinergic receptor P2X3
, ATP receptor
, P2X purinoceptor 3
, P2X receptor, subunit 3
, purinoceptor P2X3