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The product of P2RX3 belongs to the family of purinoceptors for ATP. Additionally we are shipping Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Antibodies (70) and Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins (6) and many more products for this protein.
P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.
X-ray crystal structures of the human P2X3 receptor in apo (show C9orf3 ELISA Kits)/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states
there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor (show P2RX7 ELISA Kits) in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.
Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (show P2RX1 ELISA Kits) hP2X2/3 channel.
Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) therapy.
Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (show P2RX2 ELISA Kits) and P2X3 subunits
Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.
The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2 (show P2RX2 ELISA Kits), P2X3 and P2X7 (show P2RX7 ELISA Kits) receptors in the different histological layers of the human urinary bladder.
sensory proteins P2X3 and TRPV1 (show TRPV1 ELISA Kits) are in correlation with urothelial differentiation, while P2X5 (show P2RX5 ELISA Kits) and TRPV4 (show TRPV4 ELISA Kits) have unique expression patterns
esophagitis increases mRNA expressions of P2X3 and P2X7 (show P2RX7 PLURAL_@9872@) receptors accompanied by up-regulation of TRPV1 (show TRPV1 PLURAL_@9872@) and neurotrophic factors (NGF (show NGFB PLURAL_@9872@) and GDNF (show GDNF PLURAL_@9872@)).
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A (show NPR1 ELISA Kits) pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (show BNP ELISA Kits) and facilitatory calcitonin gene-related peptide (show CALCA ELISA Kits) that both operate via complex intracellular signaling.
mouse trigeminal neurons endogenous BNP acts on NPR-A (show NPR1 ELISA Kits) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A (show NPR1 ELISA Kits)/PKG (show PRKG1 ELISA Kits) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (show P2RX2 ELISA Kits)/P2X3 knockout mice.
a slow modulatory action by BNP on TRPV1 (show TRPV1 ELISA Kits) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin
genetic manipulation of TRPV1 (show TRPV1 ELISA Kits) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.
up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (show CALCA ELISA Kits) and BDNF (show BDNF ELISA Kits) levels
Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]
interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
purinergic receptor P2X, ligand-gated ion channel, 3
, P2X3 purinoceptor
, purinergic receptor P2X3
, ATP receptor
, P2X purinoceptor 3
, P2X receptor, subunit 3
, purinoceptor P2X3