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Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins (P2RX3)

The product of P2RX3 belongs to the family of purinoceptors for ATP. Additionally we are shipping Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Antibodies (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat P2RX3 P2RX3 81739 P49654
P2RX3 5024 P56373
P2RX3 228139 Q3UR32
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Top Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
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P2RX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

More Proteins for Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaction Partners

Human Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) interaction partners

  1. P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.

  2. X-ray crystal structures of the human P2X3 receptor in apo (show C9orf3 Proteins)/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states

  3. there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor (show P2RX7 Proteins) in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.

  4. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (show P2RX1 Proteins) hP2X2/3 channel.

  5. Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (show FAM126A Proteins)) therapy.

  6. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (show P2RX2 Proteins) and P2X3 subunits

  7. Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.

  8. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2 (show P2RX2 Proteins), P2X3 and P2X7 (show P2RX7 Proteins) receptors in the different histological layers of the human urinary bladder.

  9. sensory proteins P2X3 and TRPV1 (show TRPV1 Proteins) are in correlation with urothelial differentiation, while P2X5 (show P2RX5 Proteins) and TRPV4 (show TRPV4 Proteins) have unique expression patterns

  10. esophagitis increases mRNA expressions of P2X3 and P2X7 (show P2RX7 Proteins) receptors accompanied by up-regulation of TRPV1 (show TRPV1 Proteins) and neurotrophic factors (NGF (show NGFB Proteins) and GDNF (show GDNF Proteins)).

Mouse (Murine) Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) interaction partners

  1. P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (show BNP Proteins) and facilitatory calcitonin gene-related peptide (show CALCA Proteins) that both operate via complex intracellular signaling.

  2. mouse trigeminal neurons endogenous BNP acts on NPR-A (show NPR1 Proteins) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A (show NPR1 Proteins)/PKG (show PRKG1 Proteins) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments

  3. This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (show P2RX2 Proteins)/P2X3 knockout mice.

  4. a slow modulatory action by BNP on TRPV1 (show TRPV1 Proteins) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli

  5. P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin

  6. genetic manipulation of TRPV1 (show TRPV1 Proteins) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.

  7. up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (show CALCA Proteins) and BDNF (show BDNF Proteins) levels

  8. Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]

  9. interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.

  10. An interaction between P2X3 and membrane-associated ERalpha (show ESR1 Proteins) in primary sensory neurones that may represent a novel mechanism to explain sex differences observed in the clinical presentation of visceral nociceptive syndromes.

Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Protein Profile

Protein Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

Gene names and symbols associated with P2RX3

  • purinergic receptor P2X, ligand-gated ion channel, 3 (P2RX3)
  • purinergic receptor P2X, ligand-gated ion channel, 3 (P2rx3)
  • 4930513E20Rik protein
  • P2RX3 protein
  • P2X3 protein

Protein level used designations for P2RX3

purinergic receptor P2X, ligand-gated ion channel, 3 , P2X3 purinoceptor , purinergic receptor P2X3 , ATP receptor , P2X purinoceptor 3 , P2X3 , P2X receptor, subunit 3 , purinoceptor P2X3

GENE ID SPECIES
428856 Gallus gallus
448782 Canis lupus familiaris
530468 Bos taurus
742961 Pan troglodytes
81739 Rattus norvegicus
5024 Homo sapiens
228139 Mus musculus
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