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may play a role in the formation of Purkinje cell synaptic contacts; mRNA and protein expression increase from embryonic day 17 to postpartum day 18. Additionally we are shipping Purkinje Cell Protein 4 Antibodies (22) and Purkinje Cell Protein 4 Proteins (7) and many more products for this protein.
Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown.
PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin.
PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells.
This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum.
The calmodulin (show CALM1 ELISA Kits) regulator protein, PEP-19, sensitizes ATP-induced Ca2 (show CA2 ELISA Kits)+ release.
Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation.
The PCP4 promoter is activated by Trichostatin A (TSA (show PRDX2 ELISA Kits)) treatment according to promoter reporter assays in HEK (show EPHA3 ELISA Kits) 293 cells.
PEP-19 has the potential to alter the Ca2 (show CA2 ELISA Kits)+-binding dynamics of free CaM (show CALM1 ELISA Kits) and CaM (show CALM1 ELISA Kits) that is bound to other target proteins
We further found that Pcp4 gene on the Ts1Rhr trisomic segment is expressed in ependymal cells, and its resumption to two copies rescued both ventricular enlargement and cilia dysfunction in Ts1Rhr mice.
PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms.
The PCP4 immunostaining-delineated CA2 (show CA2 ELISA Kits) neurons have distinguishable differences in cell morphology, physiology, and synaptic circuit connections compared with distal CA3 (show CA3 ELISA Kits) and proximal CA1 (show CA1 ELISA Kits) regions.
Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Data indicate that pep-19/pcp4 is a critical determinant of synaptic plasticity in cerebellum and locomotor learning.
The expression of Pcp4 in naive resting mature B cells is dependent upon tonic stimulation from the CR1/CR2 proteins via a C3 ligand.
The protein encoded by this gene regulates H1˚\; and H3.3 histone synthesis by binding to H1˚\; and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene.
brain specific polypeptide PEP19
, brain-specific antigen PCP-4
, brain-specific polypeptide PEP-19
, Neuron specific protein PEP-19 (Purkinje cell protein 4)
, neuron-specific protein PEP-19