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anti-Pyridoxamine 5'-Phosphate Oxidase (PNPO) Antibodies

The enzyme encoded by PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Additionally we are shipping PNPO Proteins (14) and PNPO Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPO 55163 Q9NVS9
PNPO 64533 O88794
PNPO 103711 Q91XF0
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Top anti-PNPO Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PNPO Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PNPO Antibody (C-term) in 293 cell line lysates (35ug/lane). PNPO (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated FACS, IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-PNPO mouse monoclonal antibody. (ABIN2455004) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PNPO (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PNPO. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-PNPO mouse monoclonal antibody. (ABIN2454900) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PNPO (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PNPO. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC200133 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PNPO antibody (ABIN2454781), and then analyzed by flow cytometry. Anti-PNPO mouse monoclonal antibody (ABIN2454781) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PNPO (RC200133). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Dog Mouse Un-conjugated IF, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PNPO (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PNPO. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated ELISA, WB PNPO polyclonal antibody (A01), Lot # 060529JCS1 Western Blot analysis of PNPO expression in MES-SA/Dx5 . Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details

PNPO Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
,
,
, , , , ,
Rat (Rattus)
,
,
Mouse (Murine)


Top referenced anti-PNPO Antibodies

  1. Cow (Bovine) Polyclonal PNPO Primary Antibody for WB - ABIN2787718 : Song, Ueno, Numata, Iga, Shibuya-Tayoshi, Nakataki, Tayoshi, Yamauchi, Sumitani, Tomotake, Tada, Tanahashi, Itakura, Ohmori: Association between PNPO and schizophrenia in the Japanese population. in Schizophrenia research 2007 (PubMed)
    Show all 2 references for ABIN2787718

  2. Human Polyclonal PNPO Primary Antibody for ELISA, WB - ABIN565829 : Khayat, Korman, Frankel, Weintraub, Hershckowitz, Sheffer, Ben Elisha, Wevers, Falik-Zaccai: PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism. in Molecular genetics and metabolism 2008 (PubMed)
    Show all 2 references for ABIN565829

  3. Human Polyclonal PNPO Primary Antibody for EIA, WB - ABIN954229 : Musayev, Di Salvo, Saavedra, Contestabile, Ghatge, Haynes, Schirch, Safo: Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN954229

  4. Human Monoclonal PNPO Primary Antibody for EIA, WB - ABIN782454 : Mills, Surtees, Champion, Beesley, Dalton, Scambler, Heales, Briddon, Scheimberg, Hoffmann, Zschocke, Clayton: Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. in Human molecular genetics 2005 (PubMed)
    Show all 2 references for ABIN782454

More Antibodies against PNPO Interaction Partners

Human Pyridoxamine 5'-Phosphate Oxidase (PNPO) interaction partners

  1. Exome sequencing revealed that the patient was compound heterozygous for pathogenic mutations [c.546+1G>A (IVS5+1 G>A) and c.620delG (p.G207VfsX215)] in the PNPO gene.

  2. One sequence variant, R116Q, a single nucleotide polymorphism that has been reported in the general population, was found to have an effect on PNPO activity.

  3. Challenge to the paradigm of exclusive PLP (show PLP1 Antibodies) responsiveness in patients with pyridoxal 5'-phosphate oxidase deficiency and underlines the importance of consecutive testing of pyridoxine and PLP (show PLP1 Antibodies) in neonates with antiepileptic drug-resistant seizures.

  4. Generalized epilepsies implicates susceptibility genes: CHRM3 (show CHRM3 Antibodies) at 1q43, VRK2 (show VRK2 Antibodies) at 2p16.1, ZEB2 (show ZEB2 Antibodies) at 2q22.3, SCN1A (show SCN1A Antibodies) at 2q24.3 and PNPO at 17q21.32.

  5. provide evidence that a single arginine residue of the C terminus of pyridoxal 5'-phosphate synthase is responsible for coordinating co-operativity in this elaborate protein machinery

  6. Results describe a combined computer and biochemical approach to characterize human pyridoxine 5'-phosphate oxidase (PNPO).

  7. We examined 8 single nucleotide polymorphisms (SNPs) in PNPO and its 5'-flanking regions in 359 schizophrenia patients and 582 control subjects.

  8. Sequencing of the PNPO gene revealed a novel homozygous nonsense mutationt in exon 3 in the neonatal and infantile seizure.

  9. PNP (show NP Antibodies) oxidase R229W mutation identified in patients with neonatal epileptic encephalopathy sgnificantly affect the catalytic efficiency of the enzyme.

PNPO Antigen Profile

Protein Summary

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

Gene names and symbols associated with PNPO

  • pyridoxine 5'-phosphate oxidase (pnpo) antibody
  • pyridoxine 5'-phosphate oxidase (pdxH) antibody
  • pyridoxamine 5'-phosphate oxidase (Mrub_2888) antibody
  • pyridoxamine 5'-phosphate oxidase (Arnit_1624) antibody
  • pyridoxamine 5'-phosphate oxidase (Ndas_4168) antibody
  • pyridoxamine 5'-phosphate oxidase (Mesil_2817) antibody
  • Pyridoxamine 5'-phosphate oxidase (Isop_0296) antibody
  • Pyridoxamine 5'-phosphate oxidase (Despr_1960) antibody
  • Pyridoxamine 5'-phosphate oxidase (Pedsa_1348) antibody
  • pyridoxamine 5'-phosphate oxidase (Mesop_5639) antibody
  • pyridoxamine 5'-phosphate oxidase (PNPO) antibody
  • pyridoxamine 5'-phosphate oxidase (Pnpo) antibody
  • pyridoxine 5'-phosphate oxidase (Pnpo) antibody
  • AI415282 antibody
  • ECK1634 antibody
  • im:7138360 antibody
  • JW1630 antibody
  • PDXPO antibody

Protein level used designations for PNPO

pyridoxine-5'-phosphate oxidase , pyridoxamine 5'-phosphate oxidase , Pyridoxamine 5'-phosphate oxidase , pyridoxal 5'-phosphate synthase , pyridoxamine-phosphate oxidase , pyridoxine 5'-phosphate oxidase , pyridoxine 5-phosphate oxidase

GENE ID SPECIES
402868 Danio rerio
946806 Escherichia coli str. K-12 substr. MG1655
8881004 Meiothermus ruber DSM 1279
9171784 Arcobacter nitrofigilis DSM 7299
9248042 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9252339 Meiothermus silvanus DSM 9946
10154400 Isosphaera pallida ATCC 43644
10174688 Desulfobulbus propionicus DSM 2032
10230903 Pedobacter saltans DSM 12145
10829504 Mesorhizobium opportunistum WSM2075
55163 Homo sapiens
480540 Canis lupus familiaris
512573 Bos taurus
64533 Rattus norvegicus
103711 Mus musculus
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