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The protein encoded by PPA1 is a member of the inorganic pyrophosphatase (PPase) family. Additionally we are shipping Pyrophosphatase (Inorganic) 1 Antibodies (56) and Pyrophosphatase (Inorganic) 1 Kits (6) and many more products for this protein.
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Human PPA1 Protein expressed in Escherichia coli (E. coli) - ABIN667664
Carman, Han: Roles of phosphatidate phosphatase enzymes in lipid metabolism. in Trends in biochemical sciences 2006
Show all 2 references for ABIN667664
PPA1 serves as a potential prognostic biomarker for patients with Ovarian serous carcinoma.
enhanced NEK2 (show NEK2 Proteins) expression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) promotes HCC (show FAM126A Proteins) progression and drug resistance by promoting PP1/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins) pathway activation, which may represent a new therapeutic target for HCC (show FAM126A Proteins).
Thus, the Ska complex, specifically the Ska1 (show SKA1 Proteins) C-terminal domain, recruits PP1 to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset.
PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer
PP-1 and Akt (show AKT1 Proteins) have roles in AR-v7 protein expression and activities when AR is functionally blocked
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Proteins), which is mediated by continual activation of PKR (show PKLR Proteins) and degradation of PP1.
The human PP1 interaction with the measles V protein is mediated by a conserved PP1-binding motif in the C-terminal region of the V protein.
Measles virus binding to DC-SIGN (show CD209 Proteins) leads to inhibition of PP1 phosphatase activity and hence inhibition of RIG-I (show DDX58 Proteins) and Mda5 (show IFIH1 Proteins) dephosphorylation.
Results identify PP1 as a novel regulator of Cl(-)-HCO3(-) anion exchangers activity which, in concert with CFTR (show CFTR Proteins), coordinates events at both apical and basolateral membranes, crucial for efficient HCO3(-) secretion from Calu (show CALU Proteins)-3 cells.
findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 (show MARK3 Proteins) and PFTK1 (show CDK14 Proteins)
PPA1 may play a role in neuronal differentiation via JNK (show MAPK8 Proteins) dephosphorylation.
IRBIT (show AHCYL1 Proteins) opposes the effects of WNKs and SPAK (show STK39 Proteins) by recruiting PP1 (show PPP1CC Proteins) to the complex to dephosphorylate CFTR (show CFTR Proteins) and NBCe1 (show SLC4A4 Proteins)-B, restoring their cell surface expression, in addition to stimulating their activities
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme.
, Inorganic pyrophosphatase
, cytosolic inorganic pyrophosphatase
, diphosphate phosphohydrolase
, inorganic diphosphatase
, inorganic pyrophosphatase 1
, pyrophosphatase 1
, pyrophosphate phospho-hydrolase