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PYCR1 encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. Additionally we are shipping Pyrroline-5-Carboxylate Reductase 1 Antibodies (57) and Pyrroline-5-Carboxylate Reductase 1 Kits (3) and many more products for this protein.
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these findings revealed that the mRNA and protein PYCR1 levels were significantly related to the poor outcome in either ER-negative or ER-positive breast cancer. PYCR1 could serve as a prognostic biomarker, therapeutic target and predictive biomarker for breast cancers.
PYCR1 forms a concentration-dependent decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically
Authors found that PYCR1 was highly expressed in prostate cancer tissues and then knocked down PYCR1 in PCa (show FLVCR1 Proteins) cell lines (DU145, PC-3 (show PCSK1 Proteins) and LNCap) via lentivirus-mediated gene delivery and analyzed its biological function.
Silencing of both PYCR1 and PYCR2 (show PYCR2 Proteins) completely abolished anti-oxidation activity of RRM2B (show RRM2B Proteins), demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
confirming that indeed PYCR1 generates L-pipecolic acid from Delta(1)-piperideine-6-carboxylate
our current study presents the second largest group of patients with PYCR1-related ARCL (show ATP6V0A2 Proteins) and expands the clinical and genetic spectrum.
Identification of two new mutations in the PYCR1 gene in patients with autosomal recessive cutis laxa, type 2.
Data suggest that DJ-1 (show PARK7 Proteins) and PYCR1 are on the same pathway of anti-oxidative stress protection of the cells.
The findings presented here suggest a mutation screening of PYCR1 and cardiovascular survey in patients with De Barsy syndrome (DBS (show MCF2L Proteins)).
Mutation analysis revealed the presence of disease-causing variants in PYCR1, including a novel deletion of the entire PYCR1 gene in one family, and in each of the other patients the homozygous missense mutations.
susceptibility to experimental pancreatitis is determined by strain and model differences with Clusterin (show CLU Proteins) and Pycr1 alterations
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.
P5C reductase 1
, mitochondrial pyrroline-5-carboxylate reductase 1
, proliferation-inducing protein 45
, pyrroline-5-carboxylate reductase 1, mitochondrial
, P5CR 1