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anti-Pyruvate Carboxylase (PC) Antibodies

PC encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. Additionally we are shipping Pyruvate Carboxylase Kits (13) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PC 18563  
PC 5091 P11498
PC 25104 P52873
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Top anti-Pyruvate Carboxylase Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB PC Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PC Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. PC Antibody (N-term) western blot analysis in mouse liver tissue lysates (35µg/lane).This demonstrates the PC antibody detected the PC protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Goat Un-conjugated ELISA, WB ABIN238663 (0.03µg/ml) staining of Mouse Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Liver (formalin-fixed, paraffin-embedded) stained with PC antibody ABIN337183 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Chicken Rabbit Un-conjugated WB Western blot analysis of Pyruvate Carboxylase expression in HEK293T (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μL Log in to see 14 Days
$201.19
Details

PC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Pyruvate Carboxylase Antibodies

  1. Human Polyclonal PC Primary Antibody for EIA, IHC (p) - ABIN954396 : MacDonald, Longacre, Langberg, Tibell, Kendrick, Fukao, Ostenson: Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes. in Diabetologia 2009 (PubMed)
    Show all 5 references for ABIN954396

  2. Cow (Bovine) Polyclonal PC Primary Antibody for WB - ABIN374944 : St Maurice, Reinhardt, Surinya, Attwood, Wallace, Cleland, Rayment: Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme. in Science (New York, N.Y.) 2007 (PubMed)

More Antibodies against Pyruvate Carboxylase Interaction Partners

Mouse (Murine) Pyruvate Carboxylase (PC) interaction partners

  1. TR4 (show NR2C2 Antibodies)-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene

  2. Repression of pyruvate carboxylase could be interpreted as a survival tactic of repressing anabolic pathways to support a redirection of limited carbon units to catabolism rather than storage

  3. Three GC boxes within the proximal promoter of the murine pyruvate carboxylase gene bind Sp1 (show SP1 Antibodies)/Sp3 (show SP3 Antibodies)

  4. CREB (show CREB1 Antibodies) bind to -1639/-1631 cyclic AMP (show TMPRSS5 Antibodies) responsive element of mouse PC gene in vitro and in vivo, respectively.

  5. PPARgamma (show PPARG Antibodies) binds to the functional PPAR (show PPARA Antibodies)-response element of the PC promoter. Impaired in vitro differentiation of white adipocytes of PPARgamma2 (show PPARG Antibodies) knock-out mice was also associated with a marked reduction of PC mRNA

  6. Focuses on cloning of human pyruvate carboxylase but also studies pyruvate carboxylase levels in mouse preadipocyte differentiation.

  7. Genomic structure of the pyruvate carboxylase gene is determined. The transcripts are highly expressed in kidney and liver, moderately expressed in heart and testis, and expressed at a low level in spleen.

Human Pyruvate Carboxylase (PC) interaction partners

  1. PC and PDH (show PDP Antibodies) may be an important part of cellular adaptation to the IDH1 (show IDH1 Antibodies) mutation and may serve as potential therapeutic targets

  2. Eight novel mutations were identified in PC from 8 pyruvate carboxylase deficiency patients.

  3. The activities of pyruvate carboxylase (PC) were decreased by 65% in pancreatic islets of patients with type 2 diabetes.

Cow (Bovine) Pyruvate Carboxylase (PC) interaction partners

  1. These data indicate that pyruvate carboxylase promoter 1 is activated by fatty acids found in serum of feed-restricted cows.

  2. Expression of pyruvate carboxylase mRNA is part of the adaptive response to feed intake restriction

Pyruvate Carboxylase (PC) Antigen Profile

Protein Summary

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

Gene names and symbols associated with PC

  • CG1516 gene product from transcript CG1516-RP (CG1516) antibody
  • pyruvate carboxylase (pc) antibody
  • PYruvate Carboxylase (pyc-1) antibody
  • pyruvate carboxylase (PC) antibody
  • pyruvate carboxylase (pyc) antibody
  • pyruvate carboxylase (pyr1) antibody
  • pyruvate carboxylase (CNF00650) antibody
  • Pyruvate carboxylase (PYC1) antibody
  • pyruvate carboxylase (Ndas_1152) antibody
  • pyruvate carboxylase (Ilyop_2503) antibody
  • pyruvate carboxylase (Calni_0495) antibody
  • pyruvate carboxylase (Ftrac_1004) antibody
  • pyruvate carboxylase (Plabr_3574) antibody
  • pyruvate carboxylase (Sgly_2936) antibody
  • pyruvate carboxylase (Celly_0558) antibody
  • pyruvate carboxylase (Hipma_0131) antibody
  • pyruvate carboxylase (Halhy_1567) antibody
  • pyruvate carboxylase (Mesop_1269) antibody
  • pyruvate carboxylase (Pcx) antibody
  • pyruvate carboxylase (Pc) antibody
  • BA4157 antibody
  • BcDNA antibody
  • BcDNA:GH06348 antibody
  • Dmel\\CG1516 antibody
  • Pc antibody
  • PCB antibody
  • Pcx antibody
  • pyc antibody
  • wu:fb82g08 antibody
  • wu:fj85g01 antibody

Protein level used designations for PC

CG1516-PA , CG1516-PB , CG1516-PD , CG1516-PE , CG1516-PG , CG1516-PI , CG1516-PJ , CG1516-PK , CG1516-PL , CG1516-PM , CG1516-PP , GH06348 , pyruvate carboxykinase , pyruvate carboxylase , PYCb , pyruvate carboxylase, mitochondrial , PYruvate Carboxylase family member (pyc-1) , Pyruvate carboxylase , pyruvate decarboxylase , pyruvic carboxylase , PCB

GENE ID SPECIES
36020 Drosophila melanogaster
58068 Danio rerio
179616 Caenorhabditis elegans
374263 Gallus gallus
1088950 Bacillus anthracis str. Ames
2539661 Schizosaccharomyces pombe 972h-
2686508 Geobacter sulfurreducens PCA
2798563 Listeria monocytogenes serotype 4b str. F2365
3195551 Ruegeria pomeroyi DSS-3
3258384 Cryptococcus neoformans var. neoformans JEC21
4840453 Scheffersomyces stipitis CBS 6054
9245002 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9870075 Ilyobacter polytropus DSM 2926
10008503 Calditerrivibrio nitroreducens DSM 19672
10011136 Marivirga tractuosa DSM 4126
10240994 Planctomyces brasiliensis DSM 5305
10250154 Syntrophobotulus glycolicus DSM 8271
10262555 Cellulophaga lytica DSM 7489
10391441 Hippea maritima DSM 10411
10585729 Haliscomenobacter hydrossis DSM 1100
10825082 Mesorhizobium opportunistum WSM2075
18563 Mus musculus
5091 Homo sapiens
338471 Bos taurus
25104 Rattus norvegicus
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