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anti-Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) Antibodies

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Additionally we are shipping PDHA1 Proteins (16) and PDHA1 Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDHA1 5160 P08559
PDHA1 29554  
PDHA1 18597 P35486
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Top anti-PDHA1 Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ICC, WB PDHA1 (C-terminus) antibody at 1/2000 dilution +HSKMC whole cell lysate 40ug/Lane, Predicted band size: 43kDa, Observed band size: 50kDa 100 μL Log in to see 8 to 9 Days
$392.86
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PDHA1 Antibody Titration: 5.0ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PDHA1 Antibody (Center) in Hela cell line lysates (35ug/lane). PDHA1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: Pyruvate Dehydrogenase E1-alpha subunit [p Ser293] Antibody [ABIN4099989] - Detection of PDHE1 alpha [S293] in an in vitro autophosphorylation of PDH complex in response to different stimulants: (-) none, H202-hydrogen peroxide, AR-anhydroretinol, Rol-retinol, RA-retinoic acid, PMA, Lipid-PKC lipid activator. -Photo courtesy of Dr. Beatrice Hoyos, Memorial Sloan-Kettering Cancer Center. Immunocytochemistry/Immunofluorescence: Pyruvate Dehydrogenase E1-alpha subunit [p Ser293] Antibody [ABIN4099989] - Pyruvate Dehydrogenase E1-alpha subunit [p Ser293] antibody (1:250) was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.05 mL Log in to see 7 to 9 Days
$473.81
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PDHA1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate Sample type:Huh7 HepG2 (50ug)Primary Antibody Dilution: 1:500Image Submitted by: Partha KasturiUniversity of Kansas Medical Center 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of PDHA1 Antibody (Center) (ABIN653604) in Hela cell line lysates (35 µg/lane). PDHA1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB PDHA1 Antibody (ABIN653605) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the PDHA1 antibody detected the PDHA1 protein (arrow). Western blot analysis of PDHA1 (arrow) using rabbit polyclonal PDHA1 Antibody (ABIN653605). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PDHA1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 7 to 9 Days
$493.17
Details

PDHA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PDHA1 Antibodies

  1. Human Polyclonal PDHA1 Primary Antibody for ICC, IF - ABIN409998 : Acin-Perez, Hoyos, Zhao, Vinogradov, Fischman, Harris, Leitges, Wongsiriroj, Blaner, Manfredi, Hammerling: Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 (PubMed)
    Show all 20 references for ABIN409998

  2. Human Polyclonal PDHA1 Primary Antibody for EIA, WB - ABIN954070 : Glushakova, Lisankie, Eruslanov, Ojano-Dirain, Zolotukhin, Liu, Srivastava, Stacpoole: AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. in Molecular genetics and metabolism 2009 (PubMed)
    Show all 3 references for ABIN954070

  3. Human Polyclonal PDHA1 Primary Antibody for IHC, ELISA - ABIN1451481 : Ross, Grafham, Coffey, Scherer, McLay, Muzny, Platzer, Howell, Burrows, Bird, Frankish, Lovell, Howe, Ashurst, Fulton, Sudbrak, Wen, Jones, Hurles, Andrews, Scott, Searle, Ramser, Whittaker, Deadman et al.: The DNA sequence of the human X chromosome. ... in Nature 2005 (PubMed)
    Show all 2 references for ABIN1451481

  4. Human Monoclonal PDHA1 Primary Antibody for ICC, WB - ABIN488246 : Dawson, Struthers: Screening for treatable left ventricular abnormalities in diabetic patients. in Expert opinion on biological therapy 2003 (PubMed)
    Show all 2 references for ABIN488246

  5. Chicken Polyclonal PDHA1 Primary Antibody for WB - ABIN2783236 : Boichard, Venet, Naas, Boutron, Chevret, de Baulny, De Lonlay, Legrand, Nordman, Brivet: Two silent substitutions in the PDHA1 gene cause exon 5 skipping by disruption of a putative exonic splicing enhancer. in Molecular genetics and metabolism 2008 (PubMed)

More Antibodies against PDHA1 Interaction Partners

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. oncoprotein HBXIP (show HBXIP Antibodies) enhances glucose metabolism reprogramming through suppressing SCO2 (show SCO2 Antibodies) and PDHA1 in breast cancer

  2. MPO (show MPO Antibodies) and BPI (show BPI Antibodies) in CD4 (show CD4 Antibodies)(+)T-lymphocytes, and PDHA1 and MRPL42 (show MRPL42 Antibodies) in CD8 (show CD8A Antibodies)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

  3. Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.

  4. High HK2 (show HK2 Antibodies) expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.

  5. In the presence of PPARbeta (show PPARD Antibodies)/delta, Vpr induced a 3.3-fold increase in PPAR (show PPARA Antibodies) response element-driven transcriptional activity, a 1.9-fold increase in PDK4 (show PDK4 Antibodies) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase (show PDP Antibodies) subunit E1alpha.

  6. In this study the phenotypes of patients with PDH (show PDP Antibodies) deficiency have been divided into three groups of mutations.

  7. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 (show PDHa2 Antibodies) gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

  8. Skin fibroblast culture assay revealed PDH (show PDP Antibodies) deficiency, confirmed by mutation analysis of the E1 alpha subunit (show POLG Antibodies).

  9. TNFalpha (show TNF Antibodies) can inhibit pulmonary artery smooth muscle cells pyruvate dehydrogenase (show PDP Antibodies) activity and induce a pulmonary arterial hypertension phenotype.

  10. We provide an efficient stepwise strategy for mutation screening in pyruvate dehydrogenase (show PDP Antibodies) complex genes and expand the growing list of PDHA1 mutations analyzed at the structural level

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The study provired that pyruvate dehydrogenase (show PDK2 Antibodies)-deficient mutant caused the retinal drficits in zebrafish.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The present findings suggest that IL-6 (show IL6 Antibodies) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  2. Liver-specific pyruvate dehydrogenase (show PDP Antibodies) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (show INS Antibodies) sensitivity.

  3. PGC-1alpha (show PPARGC1A Antibodies) regulates PDH (show PDP Antibodies)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (show PDP Antibodies) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  4. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

PDHA1 Antigen Profile

Protein Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PDHA1

  • pyruvate dehydrogenase (lipoamide) alpha 1 (pdha1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) antibody
  • PdhA1 (pdhA1) antibody
  • pyruvate dehydrogenase E1 component subunit alpha (pdhA1) antibody
  • pyruvate dehydrogenase alpha subunit protein (pdhA1) antibody
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1) antibody
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1) antibody
  • pyruvate dehydrogenase (PDHA1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1 (Pdha1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1b (pdha1b) antibody
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1) antibody
  • PDHA antibody
  • Pdha-1 antibody
  • Pdha1 antibody
  • PDHCE1A antibody
  • PHE1A antibody
  • wu:fp73b04 antibody
  • zgc:92705 antibody

Protein level used designations for PDHA1

pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase alpha 1 , fp73b04

GENE ID SPECIES
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
418610 Gallus gallus
5160 Homo sapiens
480858 Canis lupus familiaris
100294678 Sus scrofa
407109 Bos taurus
29554 Rattus norvegicus
465525 Pan troglodytes
436672 Danio rerio
18597 Mus musculus
Selected quality suppliers for anti-PDHA1 (PDHA1) Antibodies
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