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The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Additionally we are shipping PDHA1 Proteins (16) and PDHA1 Kits (14) and many more products for this protein.
Showing 10 out of 139 products:
Human Polyclonal PDHA1 Primary Antibody for ICC, IF - ABIN409998
Acin-Perez, Hoyos, Zhao, Vinogradov, Fischman, Harris, Leitges, Wongsiriroj, Blaner, Manfredi, Hammerling: Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 20 references for ABIN409998
Human Polyclonal PDHA1 Primary Antibody for EIA, WB - ABIN954070
Glushakova, Lisankie, Eruslanov, Ojano-Dirain, Zolotukhin, Liu, Srivastava, Stacpoole: AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. in Molecular genetics and metabolism 2009
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Human Polyclonal PDHA1 Primary Antibody for IHC, ELISA - ABIN1451481
Ross, Grafham, Coffey, Scherer, McLay, Muzny, Platzer, Howell, Burrows, Bird, Frankish, Lovell, Howe, Ashurst, Fulton, Sudbrak, Wen, Jones, Hurles, Andrews, Scott, Searle, Ramser, Whittaker, Deadman et al.: The DNA sequence of the human X chromosome. ... in Nature 2005
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Human Monoclonal PDHA1 Primary Antibody for ICC, WB - ABIN488246
Dawson, Struthers: Screening for treatable left ventricular abnormalities in diabetic patients. in Expert opinion on biological therapy 2003
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Chicken Polyclonal PDHA1 Primary Antibody for WB - ABIN2783236
Boichard, Venet, Naas, Boutron, Chevret, de Baulny, De Lonlay, Legrand, Nordman, Brivet: Two silent substitutions in the PDHA1 gene cause exon 5 skipping by disruption of a putative exonic splicing enhancer. in Molecular genetics and metabolism 2008
oncoprotein HBXIP (show HBXIP Antibodies) enhances glucose metabolism reprogramming through suppressing SCO2 (show SCO2 Antibodies) and PDHA1 in breast cancer
MPO (show MPO Antibodies) and BPI (show BPI Antibodies) in CD4 (show CD4 Antibodies)(+)T-lymphocytes, and PDHA1 and MRPL42 (show MRPL42 Antibodies) in CD8 (show CD8A Antibodies)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.
Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.
High HK2 (show HK2 Antibodies) expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.
In the presence of PPARbeta (show PPARD Antibodies)/delta, Vpr induced a 3.3-fold increase in PPAR (show PPARA Antibodies) response element-driven transcriptional activity, a 1.9-fold increase in PDK4 (show PDK4 Antibodies) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase (show PDP Antibodies) subunit E1alpha.
In this study the phenotypes of patients with PDH (show PDP Antibodies) deficiency have been divided into three groups of mutations.
Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 (show PDHa2 Antibodies) gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.
Skin fibroblast culture assay revealed PDH (show PDP Antibodies) deficiency, confirmed by mutation analysis of the E1 alpha subunit (show POLG Antibodies).
TNFalpha (show TNF Antibodies) can inhibit pulmonary artery smooth muscle cells pyruvate dehydrogenase (show PDP Antibodies) activity and induce a pulmonary arterial hypertension phenotype.
We provide an efficient stepwise strategy for mutation screening in pyruvate dehydrogenase (show PDP Antibodies) complex genes and expand the growing list of PDHA1 mutations analyzed at the structural level
The study provired that pyruvate dehydrogenase (show PDK2 Antibodies)-deficient mutant caused the retinal drficits in zebrafish.
The present findings suggest that IL-6 (show IL6 Antibodies) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation
Liver-specific pyruvate dehydrogenase (show PDP Antibodies) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (show INS Antibodies) sensitivity.
PGC-1alpha (show PPARGC1A Antibodies) regulates PDH (show PDP Antibodies)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (show PDP Antibodies) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.
Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
pyruvate dehydrogenase E1 alpha 1
, pyruvate dehydrogenase (lipoamide) alpha 1
, pyruvate dehydrogenase alpha subunit
, pyruvate dehydrogenase E1 component subunit alpha
, pyruvate dehydrogenase alpha subunit protein
, pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit
, precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit
, pyruvate dehydrogenase
, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
, PDHE1-A type I
, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like
, pyruvate dehydrogenase complex, E1-alpha polypeptide 1
, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
, pyruvate dehydrogenase E1 component alpha subunit
, pyruvate dehydrogenase E1alpha subunit
, pyruvate dehydrogenase alpha 1