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PDHX Proteins

(Pyruvate Dehydrogenase Complex, Component X (PDHX))
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
PDHX Protein (AA 1-109) (GST tag) PDHX Protein (AA 1-109) (GST tag) PDHX Protein (AA 1-109) (GST tag) (ABIN1314527)

PDHX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

PDHX Protein (AA 54-501) (His tag) PDHX Protein (AA 54-501) (His tag) PDHX Protein (AA 54-501) (His tag) (ABIN7124721)

PDHX Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

PDHX Protein (AA 54-501) (His tag) PDHX Protein (AA 54-501) (His tag) PDHX Protein (AA 54-501) (His tag) (ABIN3085027)

Crystallography grade PDHX Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PDHX Proteins by Grade

Find PDHX Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PDHX Proteins by Origin

Find PDHX Proteins for a variety of species such as anti-Human PDHX, anti-Mouse PDHX, anti-Cow PDHX. The species listed below are among those available. Click on a link to go to the corresponding products.

PDHX Proteins by Source

Here you will find PDHX Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PDHX Proteins by Protein Type

Here you can find PDHX Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PDHX Proteins by Application

Find PDHX Proteins validated for a specific application such as WB, ELISA, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular PDHX Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314527
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124721
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3085027
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3124972
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416460
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416508
Quantity 100 μg
Datasheet Datasheet
Reactivity Pig
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424446
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2728549
Quantity 20 μg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459716
Quantity 1 mg
Datasheet Datasheet

Aliases for PDHX Proteins

pyruvate dehydrogenase complex component X (PDHX) Proteins
pyruvate dehydrogenase complex, component X (Pdhx) Proteins
pyruvate dehydrogenase complex, component X (pdhx) Proteins
pyruvate dehydrogenase complex component X L homeolog (pdhx.L) Proteins
E3-binding protein (pdhX) Proteins
pyruvate dehydrogenase complex component X (pdhx) Proteins
Ac1164 Proteins
AI481367 Proteins
DDBDRAFT_0168431 Proteins
DDBDRAFT_0230192 Proteins
DDB_0168431 Proteins
DDB_0230192 Proteins
DLDBP Proteins
E3BP Proteins
E3bp Proteins
MGC86218 Proteins
OPDX Proteins
PDHX Proteins
PDX1 Proteins
Pdx1 Proteins
proX Proteins
zgc:66110 Proteins
zgc:85977 Proteins
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