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Pyruvate Dehydrogenase Phosphatase Proteins (PDP)

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Additionally we are shipping Pyruvate Dehydrogenase Phosphatase Antibodies (64) and Pyruvate Dehydrogenase Phosphatase Kits (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDP 11801 Q9QWK4
PDP 54705  
PDP 54704 Q9P0J1
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Top Pyruvate Dehydrogenase Phosphatase Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,314.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,314.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PDP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Pyruvate Dehydrogenase Phosphatase (PDP) Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Phosphatase (PDP) interaction partners

  1. AIM enhances intratubular debris clearance and ameliorates acute kidney injury via interaction with KIM-1 (show HAVCR1 Proteins).

  2. CD5L (show CD5L Proteins) as a critical regulator that distinguishes Th17 functional states and identified T cell lipid metabolism as an integral component of the pathways regulating Th17 cell pathogenicity.

  3. the assembled p40 (show LANCL1 Proteins)-CD5L (show CD5L Proteins) heterodimer does not recapitulate the biological activity of IL-12 (show IL12A Proteins).

  4. AIM-IgM association plays a critical role in the obesity-associated autoimmune process.

  5. AIM binds to cytosolic FAS (show FAS Proteins) protein at various regions responsible for elongation of fatty acids, release of synthesized palmitate, and stabilization of FAS (show FAS Proteins) dimerization.

  6. The protein inhibits apoptosis of T cells and NKT (show CTSL1 Proteins) cells in Corynebacterium-induced granuloma formation in mice.

  7. Bacterial lipoteichoic acid might affect the pathogenesis of epithelial inflammation followed by fibrosis in systemic multifocal epithelial inflammations in chronic colitis-harboring TCR alpha(-/-) x AIM(-/-) mice

  8. defects in PP2Cm (show PPM1K Proteins) may be responsible for a subset of human maple syrup urine disease

Human Pyruvate Dehydrogenase Phosphatase (PDP) interaction partners

  1. YB-1 (show YBX1 Proteins) phosphorylation at Ser (show SIGLEC1 Proteins)-102 is an important prerequisite for CCL5 (show CCL5 Proteins) promoter activation during macrophage differentiation

  2. the pyruvate dehydrogenase complex is regulated by Tyr (show TYR Proteins) phosphorylation of PDP1, which toggles recruitment between ACAT1 (show ACAT1 Proteins) and SIRT3 (show SIRT3 Proteins)

  3. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals.

  4. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A.

  5. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin (show INS Proteins) is greatly enhanced

  6. Lower accumulation of free ADP and AMP (show APRT Proteins) after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting.

  7. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts.

  8. In postmortem tissue samples, from male child with metabolic acidosis, PDK (show PDK2 Proteins) normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity.

Pyruvate Dehydrogenase Phosphatase (PDP) Protein Profile

Protein Summary

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with PDP

  • lethal (1) G0334 (l(1)G0334)
  • Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1-like (LOC100153002)
  • Pyruvate dehydrogenase phosphatase (Pdp)
  • pyruvate dehydrogenase phosphatase (Pdp)
  • CD5 antigen-like (Cd5l)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1)
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1)
  • 1/6 protein
  • 153332_at protein
  • AAC-11 protein
  • AI047839 protein
  • Api6 protein
  • CG7010 protein
  • CG 7010 protein
  • CG12151 protein
  • CT2 protein
  • Dmel\\CG7010 protein
  • Dmel\\CG12151 protein
  • Gm1024 protein
  • L(1)g0334 protein
  • l (1) G0334 protein
  • PDH protein
  • Pdp protein
  • PDPC protein
  • PPM2C protein
  • Sp-alpha protein

Protein level used designations for PDP

CG7010-PA , CG7010-PB , CG7010-PC , CG7010-PD , l(1)G0334-PA , l(1)G0334-PB , l(1)G0334-PC , l(1)G0334-PD , pyruvate dehydrogenase , CG12151-PA , CG12151-PB , Pdp-PA , Pdp-PB , pyruvate dehydrogenase phosphatase , AIM/Spalpha , CT-2 , Pdp 1/6 , apoptosis inhibitor 6 , apoptosis inhibitor expressed by macrophages , PDP 1 , PDPC 1 , [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial , protein phosphatase 2C, magnesium dependent, catalytic subunit , pyruvate dehydrogenase phosphatase catalytic subunit 1 , pyruvate dehydrogenase phosphatase isoenzyme 2 , protein phosphatase 2C, magnesium-dependent, catalytic subunit , pyruvate dehydrogenase phosphatase isoenzyme 1 , pyruvate dehydrogenase phosphatase, catalytic subunit 1 , pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase

GENE ID SPECIES
31406 Drosophila melanogaster
100153002 Sus scrofa
31683 Drosophila melanogaster
413080 Apis mellifera
11801 Mus musculus
381511 Mus musculus
54705 Rattus norvegicus
54704 Homo sapiens
477941 Canis lupus familiaris
280891 Bos taurus
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