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Pyruvate Kinase, Liver and RBC Proteins (PKLR)

The protein encoded by PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Additionally we are shipping Pyruvate Kinase, Liver and RBC Antibodies (142) and Pyruvate Kinase, Liver and RBC Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PKLR 18770  
PKLR 5313 P30613
PKLR 24651 P12928
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Top Pyruvate Kinase, Liver and RBC Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$367.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$272.80
Details
Yeast Rat His tag   500 μg Log in to see 56 to 66 Days
$962.50
Details
Yeast Trypanosoma brucei His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details

PKLR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
,
Human , ,
, ,
Rat (Rattus)

Top referenced Pyruvate Kinase, Liver and RBC Proteins

  1. Human PKLR Protein expressed in Escherichia coli (E. coli) - ABIN667822 : Meza, Alonso-Ferrero, Navarro, Quintana-Bustamante, Valeri, Garcia-Gomez, Bueren, Bautista, Segovia: Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. in Molecular therapy : the journal of the American Society of Gene Therapy 2009 (PubMed)
    Show all 2 references for ABIN667822

More Proteins for Pyruvate Kinase, Liver and RBC (PKLR) Interaction Partners

Mouse (Murine) Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to pyruvate kinase deficiency and leads to erythrocyte dysfunction.

  2. Pyruvate kinase deficiency in mice protects against malaria

Human Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. An update of PKLR gene mutation database has been presented. (Review)

  2. Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.

  3. PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.

  4. Pyruvate kinase variants modulate malaria phenotypes in a Thai population.

  5. 661G>A and 1528C>T mutations of PKLR gene are associated with pyruvate kinase deficiency.

  6. Case Report: unknown mutation in the pyruvate kinase gene (PKLR) identified from a neonate with severe jaundice.

  7. This study determined which interactions in the fructose 1,6-bisphosphate binding site of human liver pyruvate kinase contribute to allostery.

  8. Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 (show SLC4A1 Proteins) deficiency in a family with hereditary spherocytosis.

  9. Hemolytic anemia associated with a novel heterozygous mutation 1183A in the pyruvate kinase gene has been found in two unrelated Jordanian patients.

  10. 11 patients from 10 unrelated pyruvate kinse deficiency families had 9 different disease-causing PKLR mutations, including 2 new ones: the point mutation c.878A>T (p.Asp293Val) and the frameshift deletion c.1553delG (p.(Arg518Leufs*12).

Pig (Porcine) Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. The existence of mitochondrial Pyruvate kinase was confirmed by immunological analysis in pig liver mitochondria.

Pyruvate Kinase, Liver and RBC (PKLR) Protein Profile

Protein Summary

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PKLR

  • pyruvate kinase, liver and RBC (pklr)
  • pyruvate kinase, liver and RBC (PKLR)
  • pyruvate kinase, muscle (pkm)
  • pyruvate kinase liver and red blood cell (Pklr)
  • pyruvate kinase, liver and RBC (Pklr)
  • cthbp protein
  • oip3 protein
  • Pk-1 protein
  • PK1 protein
  • pk3 protein
  • PKL protein
  • Pklg protein
  • pklr protein
  • pkm2 protein
  • PKR protein
  • PKRL protein
  • R-PK protein
  • RPK protein
  • tcb protein
  • thbp1 protein
  • wu:fd15e01 protein
  • wu:fi37e08 protein

Protein level used designations for PKLR

pyruvate kinase isozymes R/L , pyruvate kinase, liver and RBC , Pyruvate kinase isozyme R , pyruvate kinase isozymes R/L-like , L-PK , pyruvate kinase PKLR , pyruvate kinase isozymes L/R , R-type/L-type pyruvate kinase , pyruvate kinase 1 , pyruvate kinase isozyme R/L , pyruvate kinase type L , pyruvate kinase, liver and blood cell , red cell/liver pyruvate kinase , Pyruvate kinase isozymes R/L , pyruvate kinase, liver and red blood cell

GENE ID SPECIES
114551 Danio rerio
406183 Canis lupus familiaris
469513 Pan troglodytes
549224 Xenopus (Silurana) tropicalis
719152 Macaca mulatta
100380137 Xenopus (Silurana) tropicalis
100391903 Callithrix jacchus
18770 Mus musculus
398967 Xenopus laevis
5313 Homo sapiens
490425 Canis lupus familiaris
539579 Bos taurus
24651 Rattus norvegicus
100355056 Oryctolagus cuniculus
100533203 Sus scrofa
100716756 Cavia porcellus
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