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RNA-binding protein that plays a central role in myelinization.
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Mouse (Murine) Polyclonal QK Primary Antibody for ELISA, WB - ABIN185706
Wu, Reed, Grabowski, Artzt: Function of quaking in myelination: regulation of alternative splicing. in Proceedings of the National Academy of Sciences of the United States of America 2002
we identify QKI (show QKI Antibodies) as the long-sought regulator of Neurofascin (show NFASC Antibodies) alternative splicing
Data implicate QKI (show QKI Antibodies) in the pathophysiology of inflammation and leukemoogenesis where miR (show MLXIP Antibodies)-155 is involved.
Study establish that the shk mutation, previously localized to chromosome 17, is a quaking (qk) allele consisting of a 105-nucleotide insertion in the qk regulatory region that decreases qk transcription
These results suggested that QKI5 (show QKI Antibodies) deficiency contributed to the overactivation of FoxO1 (show FOXO1 Antibodies) in ob/ob animals and subsequently magnified nitrosative stress and endoplasmic reticulum stress.
The study provides evidence that cytoplasmic quaking I-6 acts upstream of hnRNP F (show HNRNPF Antibodies)/H, which forms a novel pathway to control alternative splicing in myelinating glia.
Propose that QKI (show QKI Antibodies) is a central regulator of VSMC phenotypic plasticity and that intervention in QKI (show QKI Antibodies) activity can ameliorate pathogenic, fibroproliferative responses to vascular injury.
MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.
establish that p53 directly regulates Quaking (QKI) gene expression, and QKI protein associates with and leads to the stabilization of miR-20a
The QKI (show QKI Antibodies) RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1 (show WDR1 Antibodies).
The QKI (show QKI Antibodies)-6 RNA binding protein localizes with the MBP (show MBP Antibodies) mRNAs in stress granules of glial cells.
RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development.
, homolog of mouse quaking QKI (KH domain RNA binding protein)
, QKI-5 protein
, lethal, Chr 17, U Wisconsin 1