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RNA-binding protein that plays a central role in myelinization.
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Human Polyclonal QK Primary Antibody for WB - ABIN152579
Wang, Dimova, Cambi: PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. in Nucleic acids research 2007
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Human Polyclonal QK Primary Antibody for ICC, IF - ABIN152580
Novikov, Park, Chen, Klerman, Jalloh, Gamble: QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation. in Molecular and cellular biology 2011
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Mouse (Murine) Polyclonal QK Primary Antibody for ELISA, WB - ABIN188573
Wu, Reed, Grabowski, Artzt: Function of quaking in myelination: regulation of alternative splicing. in Proceedings of the National Academy of Sciences of the United States of America 2002
QKI (show QKI Antibodies) is involved in multiple aspects of oligodendroglial development. QKI (show QKI Antibodies) disruption can impact the cell fate of oligodendrocyte precursor cells, their migration and differentiation, and ultimately myelination in the cerebellum.
Data indicate a central role of microRNA miR-214 in embryonic stem cells (ESCs) - vascular smooth muscle cells (VSMCs) differentiation, and identified quaking (QKI) as a functional modulating target in miR-214 mediated VSMCs differentiation.
QKI (show QKI Antibodies) was strongly expressed by Muller glial cells in both the developing and adult retina. Neuronal expression was uniformly weak in the adult. QKI-5 (show QKI Antibodies) was the predominantly expressed isoform in the adult retina.
QKI (show QKI Antibodies) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 (show SIRT2 Antibodies) to facilitate oligodendrocyte differentiation.
findings reveal a crucial role for the miR (show MLXIP Antibodies)-214-Qki (show QKI Antibodies) pathway in the regulation of neuronal dendritic development.
we identify QKI (show QKI Antibodies) as the long-sought regulator of Neurofascin (show NFASC Antibodies) alternative splicing
Data implicate QKI (show QKI Antibodies) in the pathophysiology of inflammation and leukemoogenesis where miR (show MLXIP Antibodies)-155 is involved.
Study establish that the shk mutation, previously localized to chromosome 17, is a quaking (qk) allele consisting of a 105-nucleotide insertion in the qk regulatory region that decreases qk transcription
These results suggested that QKI5 (show QKI Antibodies) deficiency contributed to the overactivation of FoxO1 (show FOXO1 Antibodies) in ob/ob animals and subsequently magnified nitrosative stress and endoplasmic reticulum stress.
The study provides evidence that cytoplasmic quaking I-6 acts upstream of hnRNP F (show HNRNPF Antibodies)/H, which forms a novel pathway to control alternative splicing in myelinating glia.
RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development.
, homolog of mouse quaking QKI (KH domain RNA binding protein)
, QKI-5 protein
, lethal, Chr 17, U Wisconsin 1