anti-Quaking (QK) Antibodies

RNA-binding protein that plays a central role in myelinization.

list all antibodies Gene Name GeneID UniProt
QK 499022  
QK 19317 Q9QYS9
QK    
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Top anti-Quaking Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated ELISA, WB ABIN185706 (0.3µg/ml) staining of mouse brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated WB Western Blot: QKI/Quaking Antibody [ABIN152579] - HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-QKI antibody used for WB at 1 ug/ml.Detection: Chemiluminescence with an exposure time of 3 minutes 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: QKI/Quaking Antibody [ABIN152580] - FFPE section of mouse teratoma. Affinity purified rabbit anti-QKI used at a dilution of 1:250. Immunohistochemistry-Paraffin: QKI/Quaking Antibody [ABIN152580] - FFPE section of human breast carcinoma. Affinity purified rabbit anti-QKI used at a dilution of 1:250. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), WB Immunohistochemistry-Paraffin: QKI/Quaking Antibody [NBP2-20029] - Immunohistochemical analysis of paraffin-embedded MDA-MB157 xenograft, using antibody at 1:100 dilution. Western Blot: QKI/Quaking Antibody [NBP2-20029] - Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence: QKI/Quaking Antibody (S147-6) - Pan Specific [NBP2-42196] - Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-QKI (pan) Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. Western Blot: QKI/Quaking Antibody (S147-6) - Pan Specific [NBP2-42196] - analysis of Rat Brain Membrane showing detection of 36-38 kDa QKI (pan) protein using Mouse Anti-QKI (pan) Monoclonal Antibody, Clone S147-6 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 ug . Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-QKI (pan) Monoclonal Antibody at 1:200 for 16 hours at 4C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 36-38 kDa. 0.1 mg Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: QKI/Quaking Antibody [NBP1-87178] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Mouse Cerebral Cortex tissue Immunocytochemistry/Immunofluorescence: QKI/Quaking Antibody [NBP1-87178] - Staining of mouse dentate gyrus shows positivity in the polymorph layer neurons. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Alexa Fluor 405 ICC, IF, IHC, WB   0.1 mL Log in to see 34 Days
$538.13
Details
Human Mouse DyLight 350 ICC, IF, IHC, WB   0.1 mL Log in to see 34 Days
$538.13
Details
Human Mouse DyLight 488 ICC, IF, IHC, WB   0.1 mL Log in to see 34 Days
$538.13
Details

QK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
,

Mouse (Murine)
,

Human ,
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Top referenced anti-Quaking Antibodies

  1. Human Polyclonal QK Primary Antibody for WB - ABIN152579 : Wang, Dimova, Cambi: PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. in Nucleic acids research 2007 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal QK Primary Antibody for ICC, IF - ABIN152580 : Novikov, Park, Chen, Klerman, Jalloh, Gamble: QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation. in Molecular and cellular biology 2011 (PubMed)
    Show all 2 Pubmed References

  3. Mouse (Murine) Polyclonal QK Primary Antibody for ELISA, WB - ABIN188573 : Wu, Reed, Grabowski, Artzt: Function of quaking in myelination: regulation of alternative splicing. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)

More Antibodies against Quaking Interaction Partners

Mouse (Murine) Quaking (QK) interaction partners

  1. QKI (show QKI Antibodies) is involved in multiple aspects of oligodendroglial development. QKI (show QKI Antibodies) disruption can impact the cell fate of oligodendrocyte precursor cells, their migration and differentiation, and ultimately myelination in the cerebellum.

  2. Data indicate a central role of microRNA miR-214 in embryonic stem cells (ESCs) - vascular smooth muscle cells (VSMCs) differentiation, and identified quaking (QKI) as a functional modulating target in miR-214 mediated VSMCs differentiation.

  3. QKI (show QKI Antibodies) was strongly expressed by Muller glial cells in both the developing and adult retina. Neuronal expression was uniformly weak in the adult. QKI-5 (show QKI Antibodies) was the predominantly expressed isoform in the adult retina.

  4. QKI (show QKI Antibodies) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 (show SIRT2 Antibodies) to facilitate oligodendrocyte differentiation.

  5. findings reveal a crucial role for the miR (show MLXIP Antibodies)-214-Qki (show QKI Antibodies) pathway in the regulation of neuronal dendritic development.

  6. we identify QKI (show QKI Antibodies) as the long-sought regulator of Neurofascin (show NFASC Antibodies) alternative splicing

  7. Data implicate QKI (show QKI Antibodies) in the pathophysiology of inflammation and leukemoogenesis where miR (show MLXIP Antibodies)-155 is involved.

  8. Study establish that the shk mutation, previously localized to chromosome 17, is a quaking (qk) allele consisting of a 105-nucleotide insertion in the qk regulatory region that decreases qk transcription

  9. These results suggested that QKI5 (show QKI Antibodies) deficiency contributed to the overactivation of FoxO1 (show FOXO1 Antibodies) in ob/ob animals and subsequently magnified nitrosative stress and endoplasmic reticulum stress.

  10. The study provides evidence that cytoplasmic quaking I-6 acts upstream of hnRNP F (show HNRNPF Antibodies)/H, which forms a novel pathway to control alternative splicing in myelinating glia.

Quaking (QK) Antigen Profile

Protein Summary

RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development.

Gene names and symbols associated with anti-Quaking (QK) Antibodies

  • quaking (Qk) antibody
  • 1110003F05Rik antibody
  • 1500005P18 antibody
  • l(17)-1Wis antibody
  • l17Wis1 antibody
  • QkI antibody

Protein level used designations for anti-Quaking (QK) Antibodies

protein quaking , rqkI , homolog of mouse quaking QKI (KH domain RNA binding protein) , QKI-5 protein , lethal, Chr 17, U Wisconsin 1

GENE ID SPECIES
499022 Rattus norvegicus
19317 Mus musculus
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