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QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Additionally we are shipping QPRT Antibodies (64) and QPRT Kits (5) and many more products for this protein.
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Human QPRT Protein expressed in Escherichia coli (E. coli) - ABIN667206
Delaney, Hodson, Thakkar, Connor, Sweatman, Kenny, McGill, Holder, Hutton, Haselden, Waterfield: Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation. in Archives of toxicology 2005
Show all 2 references for ABIN667206
The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.
Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.
QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
, nicotinate-nucleotide pyrophosphorylase (carboxylating)
, nicotinate-nucleotide pyrophosphorylase [carboxylating]
, nicotinate-nucleotide pyrophosphorylase
, quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))