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RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Proteins (23) and R-Spondin 1 Kits (22) and many more products for this protein.
Showing 10 out of 62 products:
Human Monoclonal RSPO1 Primary Antibody for ELISA, WB - ABIN969375
Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: R-spondin1 is essential in sex determination, skin differentiation and malignancy. in Nature genetics 2006
Show all 2 references for ABIN969375
Human Polyclonal RSPO1 Primary Antibody for ELISA - ABIN1998217
Kamata, Katsube, Michikawa, Yamada, Takada, Mizusawa: R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. in Biochimica et biophysica acta 2004
Human Monoclonal RSPO1 Primary Antibody for WB - ABIN2869389
Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. in Human mutation 2008
R-Spondin1 has an effect on radiosensitivity of glioma cells
ZNRF3 (show ZNRF3 Antibodies) and LGR4 (show LGR4 Antibodies)-binding sites in RSPO1 are required for Wnt (show WNT2 Antibodies) signaling.
Changes in the expression levels of IRS1 (show IRS1 Antibodies), IRS2 (show IRS2 Antibodies), RIPK2 (show RIPK2 Antibodies), RSPO1, and DNA JC15 genes might contribute to the development of insulin (show INS Antibodies) resistance and glucose intolerance in the obese boys.
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
ZNRF3 (show ZNRF3 Antibodies) binds RSPO1 and LGR5 (show LGR5 Antibodies)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN Antibodies)-like 1 (Fu1) domain.
Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.
RSPO-LGR4 (show LGR4 Antibodies) not only induces the clearance of RNF43 (show RNF43 Antibodies)/ZNRF3 (show ZNRF3 Antibodies) to increase Wnt receptor levels but also recruits IQGAP1 (show IQGAP1 Antibodies) into the Wnt (show WNT2 Antibodies) signaling complex.
Crystal structures of the Lgr4 (show LGR4 Antibodies) ectodomain alone and bound to Rspo1.
In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt (show WNT2 Antibodies) signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.
Recent developments have demonstrated that ovarian development is an active process (rather than a default process); ovarian development/function requires expression of RSPO1, WNT4 (show WNT4 Antibodies), and FOXL2 (show FOXL2 Antibodies). [REVIEW]
We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Antibodies) response and mammary cell expansion
R-spondin 1/dickkopf-1 (show DKK1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) machinery is involved in testicular embryonic angiogenesis
The ascl2 (show ASCL2 Antibodies) is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt (show WNT2 Antibodies)/R-spondin can activate this regulatory loop.
RSPO1, WNT4 (show WNT4 Antibodies), and beta-catenin (show CTNNB1 Antibodies) have roles in the signaling pathway during ovarian differentiation in mice.
Rspo1 is required for ovarian differentiation by activation of the WNT (show WNT2 Antibodies)/CTNNB1 (show CTNNB1 Antibodies) signalling pathway
Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary
this study identifies Rspo1 and Wnt4 (show WNT4 Antibodies) as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.
R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland
Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes.
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
, roof plate-specific spondin-1
, ovarian R-spondin member 1
, cysteine-rich and single thrombospondin domain-containing protein 3
, thrombospondin type 1 domain containing gene Rspondin