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RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Antibodies (58) and R-Spondin 1 Proteins (24) and many more products for this protein.
Showing 10 out of 22 products:
Human RSPO1 ELISA Kit for Sandwich ELISA - ABIN572398
Choi, Chang, Cho, Kang, Shin, Song, Lee et al.: The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition ... in Scandinavian journal of rheumatology 2014
R-Spondin1 has an effect on radiosensitivity of glioma cells
ZNRF3 and LGR4 (show LGR4 ELISA Kits)-binding sites in RSPO1 are required for Wnt (show WNT2 ELISA Kits) signaling.
Changes in the expression levels of IRS1 (show IRS1 ELISA Kits), IRS2 (show IRS2 ELISA Kits), RIPK2 (show RIPK2 ELISA Kits), RSPO1, and DNA JC15 genes might contribute to the development of insulin (show INS ELISA Kits) resistance and glucose intolerance in the obese boys.
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
ZNRF3 binds RSPO1 and LGR5 (show LGR5 ELISA Kits)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN ELISA Kits)-like 1 (Fu1) domain.
Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.
RSPO-LGR4 (show LGR4 ELISA Kits) not only induces the clearance of RNF43 (show RNF43 ELISA Kits)/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 (show IQGAP1 ELISA Kits) into the Wnt (show WNT2 ELISA Kits) signaling complex.
Crystal structures of the Lgr4 (show LGR4 ELISA Kits) ectodomain alone and bound to Rspo1.
In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt (show WNT2 ELISA Kits) signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.
Recent developments have demonstrated that ovarian development is an active process (rather than a default process); ovarian development/function requires expression of RSPO1, WNT4 (show WNT4 ELISA Kits), and FOXL2 (show FOXL2 ELISA Kits). [REVIEW]
We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 ELISA Kits) response and mammary cell expansion
R-spondin 1/dickkopf-1 (show DKK1 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) machinery is involved in testicular embryonic angiogenesis
The ascl2 (show ASCL2 ELISA Kits) is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt (show WNT2 ELISA Kits)/R-spondin can activate this regulatory loop.
RSPO1, WNT4 (show WNT4 ELISA Kits), and beta-catenin (show CTNNB1 ELISA Kits) have roles in the signaling pathway during ovarian differentiation in mice.
Rspo1 is required for ovarian differentiation by activation of the WNT (show WNT2 ELISA Kits)/CTNNB1 (show CTNNB1 ELISA Kits) signalling pathway
Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary
this study identifies Rspo1 and Wnt4 (show WNT4 ELISA Kits) as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.
R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland
Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes.
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
, roof plate-specific spondin-1
, ovarian R-spondin member 1
, cysteine-rich and single thrombospondin domain-containing protein 3
, thrombospondin type 1 domain containing gene Rspondin