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R-Spondin 1 Proteins (RSPO1)

RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Antibodies (58) and R-Spondin 1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RSPO1 284654 Q2MKA7
RSPO1 313589  
RSPO1 192199 Q9Z132
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Top R-Spondin 1 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_CHO Cells Mouse His tag 100 μg Log in to see 16 Days
$492.80
Details
HOST_CHO Cells Human Un-conjugated 100 μg Log in to see 16 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human His tag 10 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_CHO Cells Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$795.30
Details

RSPO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Rat (Rattus)

Mouse (Murine) , , ,

Top referenced R-Spondin 1 Proteins

  1. Human RSPO1 Protein expressed in HEK-293 Cells - ABIN2181684 : Nam, Turcotte, Yoon: Dynamic expression of R-spondin family genes in mouse development. in Gene expression patterns : GEP 2006 (PubMed)
    Show all 4 references for ABIN2181684

  2. Mouse (Murine) RSPO1 Protein expressed in CHO Cells - ABIN2007651 : Binnerts, Kim, Bright, Patel, Tran, Zhou, Leung, Liu, Lomas, Dixon, Hazell, Wagle, Nie, Tomasevic, Williams, Zhan, Levy, Funk, Abo: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 2 references for ABIN2007651

More Proteins for R-Spondin 1 (RSPO1) Interaction Partners

Human R-Spondin 1 (RSPO1) interaction partners

  1. R-Spondin1 has an effect on radiosensitivity of glioma cells

  2. ZNRF3 (show ZNRF3 Proteins) and LGR4 (show LGR4 Proteins)-binding sites in RSPO1 are required for Wnt (show WNT2 Proteins) signaling.

  3. Changes in the expression levels of IRS1 (show IRS1 Proteins), IRS2 (show IRS2 Proteins), RIPK2 (show RIPK2 Proteins), RSPO1, and DNA JC15 genes might contribute to the development of insulin (show INS Proteins) resistance and glucose intolerance in the obese boys.

  4. the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors

  5. ZNRF3 (show ZNRF3 Proteins) binds RSPO1 and LGR5 (show LGR5 Proteins)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN Proteins)-like 1 (Fu1) domain.

  6. Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.

  7. RSPO-LGR4 (show LGR4 Proteins) not only induces the clearance of RNF43 (show RNF43 Proteins)/ZNRF3 (show ZNRF3 Proteins) to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 Proteins) signaling complex.

  8. Crystal structures of the Lgr4 (show LGR4 Proteins) ectodomain alone and bound to Rspo1.

  9. In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt (show WNT2 Proteins) signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.

  10. Recent developments have demonstrated that ovarian development is an active process (rather than a default process); ovarian development/function requires expression of RSPO1, WNT4 (show WNT4 Proteins), and FOXL2 (show FOXL2 Proteins). [REVIEW]

Mouse (Murine) R-Spondin 1 (RSPO1) interaction partners

  1. We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion

  2. R-spondin 1/dickkopf-1 (show DKK1 Proteins)/beta-catenin (show CTNNB1 Proteins) machinery is involved in testicular embryonic angiogenesis

  3. The ascl2 (show ASCL2 Proteins) is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt (show WNT2 Proteins)/R-spondin can activate this regulatory loop.

  4. RSPO1, WNT4 (show WNT4 Proteins), and beta-catenin (show CTNNB1 Proteins) have roles in the signaling pathway during ovarian differentiation in mice.

  5. Rspo1 is required for ovarian differentiation by activation of the WNT (show WNT2 Proteins)/CTNNB1 (show CTNNB1 Proteins) signalling pathway

  6. Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary

  7. this study identifies Rspo1 and Wnt4 (show WNT4 Proteins) as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.

  8. ZNRF3 (show ZNRF3 Proteins) binds RSPO1 and LGR5 (show LGR5 Proteins)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN Proteins)-like 1 (Fu1) domain.

  9. R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland

  10. Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes.

R-Spondin 1 (RSPO1) Protein Profile

Protein Summary

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.

Gene names and symbols associated with R-Spondin 1 Proteins (RSPO1)

  • R-spondin 1 (RSPO1)
  • R-spondin 1 (Rspo1)
  • R-spondin 1 (LOC100049655)
  • R-spondin homolog (Xenopus laevis) (Rspo1)
  • CRISTIN3 protein
  • R-spondin protein
  • RGD1565558 protein
  • RSPO protein
  • Rspondin protein

Protein level used designations for R-Spondin 1 Proteins (RSPO1)

R-spondin homolog , R-spondin-1 , roof plate-specific spondin-1 , ovarian R-spondin member 1 , R-spondin1 , cristin-3 , cysteine-rich and single thrombospondin domain-containing protein 3 , mCristin-3 , thrombospondin type 1 domain containing gene Rspondin

GENE ID SPECIES
284654 Homo sapiens
313589 Rattus norvegicus
100734447 Cavia porcellus
100860770 Capra hircus
100049655 Sus scrofa
608179 Canis lupus familiaris
511675 Bos taurus
419613 Gallus gallus
192199 Mus musculus
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