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RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Antibodies (58) and R-Spondin 1 Kits (22) and many more products for this protein.
Showing 10 out of 24 products:
Human RSPO1 Protein expressed in HEK-293 Cells - ABIN2181684
Nam, Turcotte, Yoon: Dynamic expression of R-spondin family genes in mouse development. in Gene expression patterns : GEP 2006
Show all 4 references for ABIN2181684
Mouse (Murine) RSPO1 Protein expressed in CHO Cells - ABIN2007651
Binnerts, Kim, Bright, Patel, Tran, Zhou, Leung, Liu, Lomas, Dixon, Hazell, Wagle, Nie, Tomasevic, Williams, Zhan, Levy, Funk, Abo: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 references for ABIN2007651
R-Spondin1 has an effect on radiosensitivity of glioma cells
ZNRF3 (show ZNRF3 Proteins) and LGR4 (show LGR4 Proteins)-binding sites in RSPO1 are required for Wnt (show WNT2 Proteins) signaling.
Changes in the expression levels of IRS1 (show IRS1 Proteins), IRS2 (show IRS2 Proteins), RIPK2 (show RIPK2 Proteins), RSPO1, and DNA JC15 genes might contribute to the development of insulin (show INS Proteins) resistance and glucose intolerance in the obese boys.
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
ZNRF3 (show ZNRF3 Proteins) binds RSPO1 and LGR5 (show LGR5 Proteins)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN Proteins)-like 1 (Fu1) domain.
Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.
RSPO-LGR4 (show LGR4 Proteins) not only induces the clearance of RNF43 (show RNF43 Proteins)/ZNRF3 (show ZNRF3 Proteins) to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 Proteins) signaling complex.
Crystal structures of the Lgr4 (show LGR4 Proteins) ectodomain alone and bound to Rspo1.
In conclusion, present study highlights the role of Rspo 1 in bone remodeling where it activates Wnt (show WNT2 Proteins) signaling to induce differentiation, as shown in human as well murine in vitro osteoblast cell models.
Recent developments have demonstrated that ovarian development is an active process (rather than a default process); ovarian development/function requires expression of RSPO1, WNT4 (show WNT4 Proteins), and FOXL2 (show FOXL2 Proteins). [REVIEW]
We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion
R-spondin 1/dickkopf-1 (show DKK1 Proteins)/beta-catenin (show CTNNB1 Proteins) machinery is involved in testicular embryonic angiogenesis
The ascl2 (show ASCL2 Proteins) is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt (show WNT2 Proteins)/R-spondin can activate this regulatory loop.
RSPO1, WNT4 (show WNT4 Proteins), and beta-catenin (show CTNNB1 Proteins) have roles in the signaling pathway during ovarian differentiation in mice.
Rspo1 is required for ovarian differentiation by activation of the WNT (show WNT2 Proteins)/CTNNB1 (show CTNNB1 Proteins) signalling pathway
Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary
this study identifies Rspo1 and Wnt4 (show WNT4 Proteins) as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.
R-spondin1 (Rspo1) as a novel hormonal mediator in the mammary gland
Findings indicate that R-spondin1 (Rspo1) is a negative regulator of beta-cell neogenesis and suggest that Rspo1 may serve as a therapeutic target for the preservation or restoration of functional [beta]-cells in diabetes.
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
, roof plate-specific spondin-1
, ovarian R-spondin member 1
, cysteine-rich and single thrombospondin domain-containing protein 3
, thrombospondin type 1 domain containing gene Rspondin