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R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\\\\; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008].. Additionally we are shipping R-Spondin 2 Proteins (8) and and many more products for this protein.
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data reveal a RSPO2-induced, LGR5 (show LGR5 Antibodies)-dependent Wnt (show WNT2 Antibodies) signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC (show CALR Antibodies) cells
results suggest that the expression of RSPO (show RSPO1 Antibodies) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
Wnt (show WNT2 Antibodies)(high) cells were more likely to give rise to Wnt (show WNT2 Antibodies)(high) progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression.
These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt (show WNT2 Antibodies) pathway.
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 (show RSPO3 Antibodies) that together occur in 10% of colon tumours
Reduced Rspo-2 levels in osteoarthritis osteoblasts are responsible, at least in part, for their reduced Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and abnormal mineralization.
Rspo2 activates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling to reduce Col2a1 (show COL2A1 Antibodies) and Sox9 (show SOX9 Antibodies) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage
High resolution crystal structure of an ectodomain variant of human LGR5 (show LGR5 Antibodies) (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2.
The endogenously expressed Lgr4 (show LGR4 Antibodies) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Antibodies)-mediated Lgr4 (show LGR4 Antibodies)-Wnt (show WNT2 Antibodies) signaling during gonadal development.
identify the transforming growth factor beta antagonist follistatin (show FST Antibodies) as a key mediator of RSPO (show RSPO1 Antibodies)-LGR4 (show LGR4 Antibodies) signaling in myogenic differentiation
Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers in the developing cochlea.
Rspo2 mutation in combination with Rspo3 (show RSPO3 Antibodies) mutation causes severe limb truncation.
Recombinant R-spondin2 and Wnt3a (show WNT3A Antibodies) up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.
Results indicate that Rspo2 and Wnt1 (show WNT1 Antibodies) have mutually distinct effects on mammary epithelial cell growth and these effects are context-dependent.
Rspo2 is a mesenchyme-derived factor that plays critical roles in regulating branchial arch 1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate.
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006
, roof plate-specific spondin-2
, activator of Wnt/beta-catenin pathway
, R-spondin 2 homolog
, R-spondin 2
, cysteine-rich and single thrombospondin domain-containing protein 2