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R-Spondin 2 Proteins (RSPO2)

R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008].. Additionally we are shipping R-Spondin 2 Antibodies (24) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat RSPO2 RSPO2 500863  
RSPO2 340419 Q6UXX9
RSPO2 239405 Q8BFU0
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Top R-Spondin 2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$492.80
Details
HOST_Human Cells Mouse Fc Tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_CHO Cells Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$630.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_CHO Cells Human Un-conjugated   20 μg Log in to see 15 to 19 Days
$314.16
Details

RSPO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

Top referenced R-Spondin 2 Proteins

  1. Human RSPO2 Protein expressed in Human Cells - ABIN2005415 : Cadieu, Neff, Quignon, Walsh, Chase, Parker, Vonholdt, Rhue, Boyko, Byers, Wong, Mosher, Elkahloun, Spady, André, Lark, Cargill, Bustamante, Wayne, Ostrander: Coat variation in the domestic dog is governed by variants in three genes. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 2 references for ABIN2005415

  2. Mouse (Murine) RSPO2 Protein expressed in Human Cells - ABIN2008573 : Kazanskaya, Glinka, del Barco Barrantes, Stannek, Niehrs, Wu: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. in Developmental cell 2004 (PubMed)
    Show all 2 references for ABIN2008573

More Proteins for R-Spondin 2 (RSPO2) Interaction Partners

Human R-Spondin 2 (RSPO2) interaction partners

  1. data reveal a RSPO2-induced, LGR5 (show LGR5 Proteins)-dependent Wnt (show WNT2 Proteins) signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC (show CALR Proteins) cells

  2. results suggest that the expression of RSPO (show RSPO1 Proteins) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population

  3. Wnt (show WNT2 Proteins)(high) cells were more likely to give rise to Wnt (show WNT2 Proteins)(high) progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression.

  4. These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt (show WNT2 Proteins) pathway.

  5. using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 (show RSPO3 Proteins) that together occur in 10% of colon tumours

  6. Reduced Rspo-2 levels in osteoarthritis osteoblasts are responsible, at least in part, for their reduced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and abnormal mineralization.

Mouse (Murine) R-Spondin 2 (RSPO2) interaction partners

  1. Rspo2 activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling to reduce Col2a1 (show COL2A1 Proteins) and Sox9 (show SOX9 Proteins) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage

  2. High resolution crystal structure of an ectodomain variant of human LGR5 (show LGR5 Proteins) (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2.

  3. The endogenously expressed Lgr4 (show LGR4 Proteins) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Proteins)-mediated Lgr4 (show LGR4 Proteins)-Wnt (show WNT2 Proteins) signaling during gonadal development.

  4. These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt (show WNT2 Proteins) pathway.

  5. identify the transforming growth factor beta antagonist follistatin (show FST Proteins) as a key mediator of RSPO (show RSPO1 Proteins)-LGR4 (show LGR4 Proteins) signaling in myogenic differentiation

  6. Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers in the developing cochlea.

  7. Rspo2 mutation in combination with Rspo3 (show RSPO3 Proteins) mutation causes severe limb truncation.

  8. Recombinant R-spondin2 and Wnt3a (show WNT3A Proteins) up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.

  9. Results indicate that Rspo2 and Wnt1 (show WNT1 Proteins) have mutually distinct effects on mammary epithelial cell growth and these effects are context-dependent.

  10. Rspo2 is a mesenchyme-derived factor that plays critical roles in regulating branchial arch 1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate.

R-Spondin 2 (RSPO2) Protein Profile

Protein Summary

R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006

Gene names and symbols associated with R-Spondin 2 Proteins (RSPO2)

  • R-spondin 2 (Rspo2)
  • R-spondin 2 (rspo2)
  • R-spondin 2 (RSPO2)
  • R-spondin 2 homolog (Xenopus laevis) (Rspo2)
  • 2610028F08Rik protein
  • AA673245 protein
  • CRISTIN2 protein
  • D430027K22 protein
  • ftls protein
  • RGD1562331 protein

Protein level used designations for R-Spondin 2 Proteins (RSPO2)

R-spondin-2 , XRspo2 , roof plate-specific spondin-2 , activator of Wnt/beta-catenin pathway , R-spondin 2 homolog , R-spondin 2 , cristin-2 , cysteine-rich and single thrombospondin domain-containing protein 2 , mCristin-2

GENE ID SPECIES
500863 Rattus norvegicus
496383 Xenopus laevis
496854 Xenopus (Silurana) tropicalis
536121 Bos taurus
697376 Macaca mulatta
100056523 Equus caballus
340419 Homo sapiens
239405 Mus musculus
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