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RABL2A is a member of the RAB gene family which belongs to the RAS GTPase superfamily. Additionally we are shipping RAB, Member of RAS Oncogene Family-Like 2A Proteins (3) and many more products for this protein.
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CEP19 is recruited to the ciliary base by the centriolar CEP350 (show CEP350 Antibodies)/FOP (show CHTOP Antibodies) complex and then specifically captures GTP (show AK3 Antibodies)-bound RABL2B (show RABL2B Antibodies), which is activated via its intrinsic nucleotide exchange.
RABL2 dysfunction, even in mice fed a low-fat chow diet, leads to retarded hepatic mitochondria movement associated with and a cascading phenotype of interrelated metabolic defects reminiscent of a type 2 diabetic state: hepatic steatosis, insulin (show INS Antibodies) resistance, glucose intolerance, and adult onset obesity.
Our data demonstrate a novel function for the RABL (show Rab5c Antibodies) protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum.
In human samples no deviations of the euploid genomic state could be detected indicating that 22q13 microdeletions involving RABL2B (show RABL2B Antibodies) are rare.
Suggest the 114391996 delC allele in the RABL2A gene may act as a risk factor for oligoasthenospermic infertility in Australian men.
This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Two alternatively spliced transcript variants have been identified, both encoding the same protein.
RAB, member of RAS oncogene family-like 2A
, rab-like protein 2B
, rab-like protein 2A
, RAB, member of RAS oncogene family-like 2B