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RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010].. Additionally we are shipping RABGEF1 Proteins (5) and RABGEF1 Kits (3) and many more products for this protein.
Showing 10 out of 28 products:
Chicken Monoclonal RABGEF1 Primary Antibody for IF, WB - ABIN968878
Horiuchi, Lippé, McBride, Rubino, Woodman, Stenmark, Rybin, Wilm, Ashman, Mann, Zerial: A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. in Cell 1997
Show all 3 references for ABIN968878
Human Polyclonal RABGEF1 Primary Antibody for EIA, WB - ABIN783421
Zhu, Liang, Li: Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. in Molecular biology of the cell 2009
Show all 2 references for ABIN783421
Human Polyclonal RABGEF1 Primary Antibody for ICC, IF - ABIN4348995
Lucitti, Sealock, Buckley, Zhang, Xiao, Dudley, Faber: Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. in Stroke 2016
The results contradict the model of feedback activation of Rab5 (show RAB5A Antibodies) and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 (show RAB4A Antibodies) to activate Rab5 (show RAB5A Antibodies) in a feed-forward manner.
RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients
Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis.
analysis of Rabex-5 GEF (show SLC2A4RG Antibodies) activation by Rabaptin-5 (show RABEP1 Antibodies)
This implies that Rap (show LRPAP1 Antibodies) regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated
RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy.
Interaction of Rabex-5 with Rab5 (show RAB5A Antibodies) depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization.
KCa2.3 (show KCNN3 Antibodies) is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin (show DNM1 Antibodies)- and Rab5 (show RAB5A Antibodies)-dependent manner.
a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.
RABEX-5 and RAB5 (show RAB5A Antibodies) may be involved in the development of breast cancer metastasis.
Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells.
Hyperinsulinemia induced insulin (show INS Antibodies) resistance in 3T3-L1 adipocytes by retaining GLUT4 (show SLC2A4 Antibodies) in a Rab5 (show RAB5A Antibodies)-activity-dependent compartment.
Kruppel-like factor 5 (show KLF5 Antibodies) is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5 (show RAB5A Antibodies)-dependent post-translational regulation of beta1/beta2 integrins
Rab5 (show RAB5A Antibodies) is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages.
Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (show RAB5A Antibodies), which is localized in both axons and dendrites, and Rab17 (show RAB17 Antibodies), which is localized in dendrites alone
Data show that RabGEF1 can negatively regulate thymic stromal lymphopoietin (TSLP (show TSLP Antibodies)) production in vivo and that excessive production of TSLP (show TSLP Antibodies) contributes to many of the phenotypic abnormalities in Rabgef1-/- mice.
Data reveal the affinity of Rabex-5/Rabaptin-5 (show RABEP1 Antibodies)/Rab5 (show RAB5A Antibodies)-GTP (show AK3 Antibodies) interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway.
Data report the identification of Rab22 (show RAD51AP1 Antibodies) as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5 (show RAB5A Antibodies), establishing a Rab22 (show RAD51AP1 Antibodies)-Rab5 (show RAB5A Antibodies) signaling relay to promote early endosome fusion.
RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo.
these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Receptor recycling is mediated by AP-1 (show JUN Antibodies)/clathrin-coated vesicles and regulated by rab4 (show RAB4A Antibodies) and rabaptin-5 (show RABEP1 Antibodies)/rabex-5.
Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 (show RAB5A Antibodies) in a Rabaptin-5 (show RABEP1 Antibodies)-independent manner in vivo.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor (show ARHGEF12 Antibodies) activity and of Rab5 (show RAB5A Antibodies).
RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997
, rab5 GDP/GTP exchange factor
, rabaptin-5-associated exchange factor for Rab5
, Rab5 exchange factor
, Ras negative regulator Rabex-5
, Ras negative regulator Rabex-5/Rin2
, Rab5 guanine nucleotide exchange factor Rabex-5