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The protein encoded by RAB18 is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Additionally we are shipping RAB18 Antibodies (34) and many more products for this protein.
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Human RAB18 Protein expressed in Escherichia coli (E. coli) - ABIN667980
McMurtrie, Barbosa, Zerial, Kingsmore: Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. in Genomics 1998
Show all 2 references for ABIN667980
findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people.
RAB18 is the direct target of miR (show MLXIP Proteins)-455-5p in gastric cancer.
Warburg Micro syndrome is caused by RAB18 deficiency.
These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets.
High RAB18 expression is associated with glioma.
Rab18-mediated membrane trafficking of FASN (show FASN Proteins) and NS3 facilitates dengue virus replication.
Rab18 and a Rab18 GEF complex of Rab3GAP1 and Rab3GAP2 have roles in the endoplasmic reticulum structure
Rab18 interacts with the HCV nonstructural protein NS5A.
One-hundred and forty-four Micro and nine Martsolf families were investigated, identifying mutations in RAB3GAP1 (show RAB3GAP1 Proteins) in 41% of cases, mutations in RAB3GAP2 in 7% of cases, and mutations in RAB18 in 5% of cases
Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18.
RAB18 regulates neuronal migration and morphogenesis during development.
Retinoid and cholesterol metabolism are linked in stellate cells by the LD-associated protein Rab18 and may have significant therapeutic benefit in liver fibrosis.
The results of this study indicated that the sensory nervous system is more vulnerable to Rab18 deficiency and WARBM is not only a neurodevelopmental but also neurodegenerative disease.
apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic interventions
Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6 (show RAB6A Proteins), Rab10 (show RAB10 Proteins), and Rab14 (show RAB14 Proteins)) localizes to the peroxisomal compartment.
Rab18 regulates lipid droplet-associated membrane formation
results show that a Rab (show HRB Proteins) protein localizes directly to the monolayer surface of lipid droplets
in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
RAB18, member RAS oncogene family
, RAB18 small GTPase
, Ras-related protein Rab-18
, ras-related protein Rab-18
, GTP-binding protein Rab18