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RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM, Nov 2008].. Additionally we are shipping RAB21 Proteins (11) and many more products for this protein.
Showing 10 out of 67 products:
Human Monoclonal RAB21 Primary Antibody for IF, WB - ABIN395106
Burgo, Sotirakis, Simmler, Verraes, Chamot, Simpson, Lanzetti, Proux-Gillardeaux, Galli: Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. in EMBO reports 2009
Show all 5 references for ABIN395106
Human Polyclonal RAB21 Primary Antibody for EIA, IF - ABIN1449947
Opdam, Kamps, Croes, van Bokhoven, Ginsel, Fransen: Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. in European journal of cell biology 2000
Human Monoclonal RAB21 Primary Antibody for ELISA, WB - ABIN524911
Mai, Veltel, Pellinen, Padzik, Coffey, Marjomäki, Ivaska: Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. in The Journal of cell biology 2011
Human Polyclonal RAB21 Primary Antibody for IHC (p), WB - ABIN657300
Eathiraj, Pan, Ritacco, Lambright: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. in Nature 2005
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 (show VAMP8 Antibodies) to promote autophagosome-lysosome fusion.
High RAB21 expression is associated with glioma.
Taken together, these data suggest that Rab21 plays a negative role in the EGF (show EGF Antibodies)-mediated MAPK (show MAPK1 Antibodies) signaling pathway. Overexpression of Rab21 attenuated EGF (show EGF Antibodies)-mediated mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling by inducing EGFR (show EGFR Antibodies) degradation.
Rab21 (and Rab5 (show RAB5A Antibodies)) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP (show AK3 Antibodies)/GDP cycle and proper membrane targeting
Results show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21.
show that TI-VAMP (show VAMP7 Antibodies) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp (show ANKRD27 Antibodies), a guanine nucleotide exchange factor (show RASGRF1 Antibodies) of the small GTPase (show RACGAP1 Antibodies) Rab21, through a specific domain herein called the interacting domain.
this novel finding that Rab21 regulates SSTR3 (show SSTR3 Antibodies) trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Mechanistically, p120RasGAP (show RASA1 Antibodies) interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with Rab21 for binding to endocytosed integrins.
data indicate that Rab21 is a transient component of early and intermediate stages of macropinocytosis, and probably functions in macropinosome maturation before fusing with lysosomal compartments
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000
ras-related protein Rab-21
, RAB21, member RAS oncogene family