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RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM, Nov 2008].. Additionally we are shipping RAB21 Antibodies (65) and RAB21 Proteins (11) and many more products for this protein.
Starvation-induced MTMR13 (show SBF2 ELISA Kits) and RAB21 activity regulates VAMP8 (show VAMP8 ELISA Kits) to promote autophagosome-lysosome fusion.
High RAB21 expression is associated with glioma.
Taken together, these data suggest that Rab21 plays a negative role in the EGF (show EGF ELISA Kits)-mediated MAPK (show MAPK1 ELISA Kits) signaling pathway. Overexpression of Rab21 attenuated EGF (show EGF ELISA Kits)-mediated mitogen-activated protein kinase (show MAPK1 ELISA Kits) (MAPK (show MAPK1 ELISA Kits)) signaling by inducing EGFR (show EGFR ELISA Kits) degradation.
Rab21 (and Rab5 (show RAB5A ELISA Kits)) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP (show AK3 ELISA Kits)/GDP cycle and proper membrane targeting
Results show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21.
show that TI-VAMP (show VAMP7 ELISA Kits) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp (show ANKRD27 ELISA Kits), a guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) of the small GTPase (show RACGAP1 ELISA Kits) Rab21, through a specific domain herein called the interacting domain.
this novel finding that Rab21 regulates SSTR3 (show SSTR3 ELISA Kits) trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Mechanistically, p120RasGAP (show RASA1 ELISA Kits) interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with Rab21 for binding to endocytosed integrins.
data indicate that Rab21 is a transient component of early and intermediate stages of macropinocytosis, and probably functions in macropinosome maturation before fusing with lysosomal compartments
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000
ras-related protein Rab-21
, RAB21, member RAS oncogene family