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The protein encoded by RAB23 belongs to the small GTPase superfamily, Rab family. Additionally we are shipping RAB23 Antibodies (72) and many more products for this protein.
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Human RAB23 Protein expressed in Escherichia coli (E. coli) - ABIN667606
Eggenschwiler, Espinoza, Anderson: Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. in Nature 2001
Show all 2 references for ABIN667606
this study showed that Rab23 regulates Nodal signaling in left- right patterning of th emouse and zebrafish.
Our findings have uncovered a hitherto unknown effector of Rab23 and demonstrate how Rab23 could mediate the transport of Kif17 (show KIF17 Proteins) to the primary cilium
D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17 (show KIF17 Proteins). This targeting mechanism critically depends on Rab23.
Rab23 regulates subcellular localization of essential components of the Hedgehog (show SHH Proteins) pathway that act downstream of Smoothened and upstream of Gli (show GLI1 Proteins) proteins.
Expression of Rab23 in the adult brain is suggestive, however, of having a postnatal function beyond its role in embryonic development.
Rab23 functions downstream of Smo and affects the function of the Shh (show SHH Proteins)-regulated Gli (show GLI1 Proteins) family of transcription factors
Rab23 is involved in the control of Sox9 (show SOX9 Proteins) expression via Gli1 (show GLI1 Proteins) protein
Forced expression of MiR (show MLXIP Proteins)-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR (show MLXIP Proteins)-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target
Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1.
Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression
Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis.
Rab23 was a target gene of miR (show MLXIP Proteins)-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR (show MLXIP Proteins)-367.
The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1 (show GLI1 Proteins).
Rab23 expression level was the highest in Bcap-37 (show PHB2 Proteins) cells.
Rab9A (show RAB9A Proteins) and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus.
Rab23 directly associates with Su(Fu (show SUFUH Proteins)) and inhibits Gli1 (show GLI1 Proteins) function in a Su(Fu (show SUFUH Proteins))-dependent manner.
association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
RAB23, member RAS oncogene family
, Ras-related protein Rab-23
, ras-related protein Rab-23
, open brain 2
, protein open brain
, RAB family small GTP binding protein RAB 23