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Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010].. Additionally we are shipping RAB27B Proteins (13) and RAB27B Kits (1) and many more products for this protein.
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Human Polyclonal RAB27B Primary Antibody for EIA, IHC (p) - ABIN954410
Hayasaka, Terada, Suzuki, Murakawa, Tachibana, Sankai, Murakami, Yaegashi, Okamura: Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. in Asian journal of andrology 2008
Show all 4 references for ABIN954410
Human Polyclonal RAB27B Primary Antibody for IHC (p), WB - ABIN656670
Hendrix, Maynard, Pauwels, Braems, Denys, Van den Broecke, Lambert, Van Belle, Cocquyt, Gespach, Bracke, Seabra, Gahl, De Wever, Westbroek: Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. in Journal of the National Cancer Institute 2010
Show all 2 references for ABIN656670
Human Polyclonal RAB27B Primary Antibody for FACS, WB - ABIN651177
Tiwari, Italiano, Barral, Mules, Novak, Swank, Seabra, Shivdasani: A role for Rab27b in NF-E2-dependent pathways of platelet formation. in Blood 2003
Rab27b enrichment occurs early in secretory vesicle formation.
Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.
Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.
MiR (show MLXIP Antibodies)-193a-3p and miR (show MLXIP Antibodies)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR (show SRR Antibodies) genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma
These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D (show RAB3D Antibodies).
Experimental data are reviewed with a focus on the secretory Rab27 (show RAB27A Antibodies) family of small GTPases and their implications in cancer progression.
Decreased invasion partly resulted from reduced expression and activation of MMP-9 (show MMP9 Antibodies) after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo.
Data indicate that the secretion of microRNA miR (show MLXIP Antibodies)-143, depends on rab (show HRB Antibodies) GTP-binding (show RND2 Antibodies) proteins Rab7a (show RAB7A Antibodies) and Rab27b.
Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.
Silencing of the exocytotic RAB (show HRB Antibodies) family members RAB27A (show RAB27A Antibodies) or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion.
inhibiting V-ATPase (show ATP6V1H Antibodies) activity by interfering agents and drugs might be an effective strategy for blocking Rab27B-dependent proinvasive secretory vesicle trafficking in ERalpha (show ESR1 Antibodies)-positive breast cancer patients
findings suggest that overexpression of Rab27B in BC coincides with lymph node metastasis and acquisition of a poor prognostic phenotype
These results suggest that Rab27b negatively regulates the cell surface expression of c-kit (show KIT Antibodies) via secretion of SCF (show KITLG Antibodies) and that ligation of SCF (show KITLG Antibodies) leads to the endolysosomal degradation system of c-kit (show KIT Antibodies).
Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b (show RAB27A Antibodies) double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 (show CXCL2 Antibodies) and LTB4 (show PTGR1 Antibodies).
EPI64B (show TBC1D10B Antibodies) can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.
Expression of Rab27b DN constructs resulted in dispersed collagen vesicles which may represent failed secretory vesicles sequestered in the cytosol.
Data suggest that Rab27a (show RAB27A Antibodies) and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A Antibodies)/Mlph (show MLPH Antibodies)/MyoVa (show MYO5A Antibodies) regulating cortical actin stability upstream of Rab27a/b (show RAB27A Antibodies)/Munc13-4 (show UNC13D Antibodies)-dependent granule exocytosis.
Data indicate that inhibition of Rab27a (show RAB27A Antibodies), but not Rab27b, affects exosome secretion.
Stimulation-dependent lysosomal RANKL (show TNFSF11 Antibodies) release is mediated by Rab27a/b (show RAB27A Antibodies) and their effector molecules, and this mechanism may be important for osteoclast activation in vivo.
Morphological changes observed at the ultrastructural level in Rab27b-deficient lung samples result from secretory defects in alveolar epithelial type II and Clara cells that, over time, lead to atrophy of the epithelium.
Both Rab27a (show RAB27A Antibodies) and Rab27b deficiencies impaired azurophilic granule exocytosis. Rab27a (show RAB27A Antibodies)(ash/ash) neutrophils showed upregulation of Rab27b expression which did not compensate for the secretory defects observed in Rab27a (show RAB27A Antibodies)-deficient cells.
Chromosomal mapping and gene structure of the RAB27B gene.
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997
RAB27B, member RAS oncogene family
, ras-related protein Rab-27B