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Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010].. Additionally we are shipping RAB27B Antibodies (66) and RAB27B Kits (1) and many more products for this protein.
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Human RAB27B Protein expressed in Escherichia coli (E. coli) - ABIN667319
Ostrowski, Carmo, Krumeich, Fanget, Raposo, Savina, Moita, Schauer, Hume, Freitas, Goud, Benaroch, Hacohen, Fukuda, Desnos, Seabra, Darchen, Amigorena, Moita, Thery: Rab27a and Rab27b control different steps of the exosome secretion pathway. in Nature cell biology 2009
Show all 2 references for ABIN667319
Rab27b enrichment occurs early in secretory vesicle formation.
Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.
Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.
decreased expression of Rab27A (show RAB27A Proteins) and Rab27B, especially Rab27A (show RAB27A Proteins), closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
Data indicate that a significant correlation between rab (show HRB Proteins) GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53 (show TP53 Proteins)) expression was observed.
MiR (show MLXIP Proteins)-193a-3p and miR (show MLXIP Proteins)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR (show SRR Proteins) genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma
These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D (show RAB3D Proteins).
Experimental data are reviewed with a focus on the secretory Rab27 (show RAB27A Proteins) family of small GTPases and their implications in cancer progression.
Decreased invasion partly resulted from reduced expression and activation of MMP-9 (show MMP9 Proteins) after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo.
Data indicate that the secretion of microRNA miR (show MLXIP Proteins)-143, depends on rab (show HRB Proteins) GTP-binding (show RND2 Proteins) proteins Rab7a (show RAB7A Proteins) and Rab27b.
Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.
Silencing of the exocytotic RAB (show HRB Proteins) family members RAB27A (show RAB27A Proteins) or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion.
inhibiting V-ATPase (show ATP6V1H Proteins) activity by interfering agents and drugs might be an effective strategy for blocking Rab27B-dependent proinvasive secretory vesicle trafficking in ERalpha (show ESR1 Proteins)-positive breast cancer patients
Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b (show RAB27A Proteins) double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 (show CXCL2 Proteins) and LTB4 (show PTGR1 Proteins).
EPI64B (show TBC1D10B Proteins) can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.
Expression of Rab27b DN constructs resulted in dispersed collagen vesicles which may represent failed secretory vesicles sequestered in the cytosol.
Data suggest that Rab27a (show RAB27A Proteins) and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (show RAB27A Proteins)/Mlph (show MLPH Proteins)/MyoVa (show MYO5A Proteins) regulating cortical actin stability upstream of Rab27a/b (show RAB27A Proteins)/Munc13-4 (show UNC13D Proteins)-dependent granule exocytosis.
Data indicate that inhibition of Rab27a (show RAB27A Proteins), but not Rab27b, affects exosome secretion.
Stimulation-dependent lysosomal RANKL (show TNFSF11 Proteins) release is mediated by Rab27a/b (show RAB27A Proteins) and their effector molecules, and this mechanism may be important for osteoclast activation in vivo.
Morphological changes observed at the ultrastructural level in Rab27b-deficient lung samples result from secretory defects in alveolar epithelial type II and Clara cells that, over time, lead to atrophy of the epithelium.
Both Rab27a (show RAB27A Proteins) and Rab27b deficiencies impaired azurophilic granule exocytosis. Rab27a (show RAB27A Proteins)(ash/ash) neutrophils showed upregulation of Rab27b expression which did not compensate for the secretory defects observed in Rab27a (show RAB27A Proteins)-deficient cells.
Chromosomal mapping and gene structure of the RAB27B gene.
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997
RAB27B, member RAS oncogene family
, ras-related protein Rab-27B