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In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Additionally we are shipping RAB35 Proteins (7) and RAB35 Kits (1) and many more products for this protein.
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Human Polyclonal RAB35 Primary Antibody for WB - ABIN2784851
Kley, Maerkens, Leber, Theis, Schreiner, van der Ven, Uszkoreit, Stephan, Eulitz, Euler, Kirschner, Müller, Meyer, Tegenthoff, Fürst, Vorgerd, Müller, Marcus: A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients. in Molecular & cellular proteomics : MCP 2012
Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.
the activation-inactivation cycles of Rab35 and ARF6 (show ARF6 Antibodies) are required for the uptake of zymosan and that ACAP2 (show ACAP2 Antibodies) is an important component that links Rab35/ARF6 (show ARF6 Antibodies) signaling during phagocytosis of zymosan.
Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling, suppress apoptosis, and transform cells in a PI3K (show PIK3CA Antibodies)-dependent manner.
mutual regulation with arf6 (show ARF6 Antibodies) of cell adhesion and migration
Rab35 acts as a downstream target of Dvl2 (show DVL2 Antibodies) and mediates cell migration.
Activated ARF6 (show ARF6 Antibodies) reduces Rab35 loading into the endocytic pathway.
whereas connecdenn 1 and 2 activate Rab35 for endosomal trafficking, connecdenn 3 uniquely activates Rab35 for its role in actin regulation
analysis of DENND1B (show DENND1B Antibodies)-S complexed with its substrate Rab35
the phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) 5-phosphatase OCRL (show OCRL Antibodies), which is mutated in Lowe syndrome patients, is an effector of the Rab35 GTPase (show RACGAP1 Antibodies) in cytokinesis abscission
A Small Ras-like GTPase (show RAB40C Antibodies) protein Ray was indicated to modulate p53 (show TP53 Antibodies) transcriptional activity of PRPK (show TP53RK Antibodies).
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Rab35 regulates phagosome formation through recruitment of ACAP2 (show ACAP2 Antibodies) in macrophages during FcgammaR-mediated phagocytosis.
The minimal functional Rab35-binding site of RUSC2 (show RUSC2 Antibodies) was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (show AK3 Antibodies)-Rab35-specific trapper.
Rab35 colocalizes with actin filaments and with Cdc42 (show CDC42 Antibodies), Rac1 and RhoA (show RHOA Antibodies), and that Rab35 can activate Cdc42 (show CDC42 Antibodies) both in vivo and in vitro
study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin (show FSCN1 Antibodies), which directly associated with active Rab35
In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.
RAB35, member RAS oncogene family
, ras-related protein Rab-35
, GTP-binding protein RAY
, ras-related protein rab-1c (GTP-binding protein ray)