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In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Additionally we are shipping RAB35 Antibodies (64) and RAB35 Proteins (7) and many more products for this protein.
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Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.
Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.
the activation-inactivation cycles of Rab35 and ARF6 (show ARF6 ELISA Kits) are required for the uptake of zymosan and that ACAP2 (show ACAP2 ELISA Kits) is an important component that links Rab35/ARF6 (show ARF6 ELISA Kits) signaling during phagocytosis of zymosan.
Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling, suppress apoptosis, and transform cells in a PI3K (show PIK3CA ELISA Kits)-dependent manner.
mutual regulation with arf6 (show ARF6 ELISA Kits) of cell adhesion and migration
Rab35 acts as a downstream target of Dvl2 (show DVL2 ELISA Kits) and mediates cell migration.
Activated ARF6 (show ARF6 ELISA Kits) reduces Rab35 loading into the endocytic pathway.
whereas connecdenn 1 and 2 activate Rab35 for endosomal trafficking, connecdenn 3 uniquely activates Rab35 for its role in actin regulation
analysis of DENND1B (show DENND1B ELISA Kits)-S complexed with its substrate Rab35
the phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) 5-phosphatase OCRL, which is mutated in Lowe syndrome patients, is an effector of the Rab35 GTPase (show RACGAP1 ELISA Kits) in cytokinesis abscission
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Rab35 regulates phagosome formation through recruitment of ACAP2 (show ACAP2 ELISA Kits) in macrophages during FcgammaR-mediated phagocytosis.
The minimal functional Rab35-binding site of RUSC2 (show RUSC2 ELISA Kits) was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (show AK3 ELISA Kits)-Rab35-specific trapper.
Rab35 colocalizes with actin filaments and with Cdc42 (show CDC42 ELISA Kits), Rac1 and RhoA (show RHOA ELISA Kits), and that Rab35 can activate Cdc42 (show CDC42 ELISA Kits) both in vivo and in vitro
study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin (show FSCN1 ELISA Kits), which directly associated with active Rab35
In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.
RAB35, member RAS oncogene family
, ras-related protein Rab-35
, GTP-binding protein RAY
, ras-related protein rab-1c (GTP-binding protein ray)