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RAB39B encodes a member of the Rab family of proteins. Additionally we are shipping RAB39B Antibodies (43) and many more products for this protein.
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RAB39B mutations are a rare finding in Parkinson disease patients
RAB39B is an essential regulator of vesicular-trafficking in clinically typical Parkinson's disease
RAB39B selectively regulates GluA2 (show GRIA2 Proteins) trafficking to determine synaptic AMPAR composition
The loss of RAB39B results in dysregulation of alpha-synuclein homeostasis and a spectrum of neuropathological features that implicate RAB39B in the pathogenesis of Parkinson disease and potentially other neurodegenerative disorders.
increased dosage of RAB39B causes a disturbed neuronal development leading to cognitive impairment
Data indicate that myosin Va (show MYO5A Proteins) interacted with multiple new Rab (show HRB Proteins) subfamilies including Rab6 (show RAB6A Proteins), Rab14 (show RAB14 Proteins) and Rab39B.
These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities.
RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28.
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.
RAB39B, member RAS oncogene family
, ras-related protein Rab-39B-like
, ras-related protein Rab-39B