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may play a role in intracellular recruitment of the glucose transporter GLUT4. Additionally we are shipping RAB4A, Member RAS Oncogene Family Proteins (8) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN361841
Ali, Wasmeier, Lamoreux, Strom, Seabra: Multiple regions contribute to membrane targeting of Rab GTPases. in Journal of cell science 2004
Show all 8 references for ABIN361841
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN2486637
Ayad, Hull, Mellman: Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes. in The EMBO journal 1997
Show all 6 references for ABIN2486637
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN2486639
Takai, Sasaki, Matozaki: Small GTP-binding proteins. in Physiological reviews 2001
Show all 6 references for ABIN2486639
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN2486644
Zerial, McBride: Rab proteins as membrane organizers. in Nature reviews. Molecular cell biology 2001
Show all 6 references for ABIN2486644
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN2486640
Cormont, Bortoluzzi, Gautier, Mari, van Obberghen, Le Marchand-Brustel: Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes. in Molecular and cellular biology 1997
Show all 6 references for ABIN2486640
Human Polyclonal RAB4A Primary Antibody for ICC, IF - ABIN2486641
van der Sluijs, Hull, Huber, Mâle, Goud, Mellman: Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle. in The EMBO journal 1992
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Dog (Canine) Monoclonal RAB4A Primary Antibody for IF, WB - ABIN968232
Huang, Imamura, Olefsky: Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 5 references for ABIN968232
Human Monoclonal RAB4A Primary Antibody for FACS, IHC - ABIN969558
Ferrándiz-Huertas, Fernández-Carvajal, Ferrer-Montiel: Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells. in International journal of cancer. Journal international du cancer 2010
The results contradict the model of feedback activation of Rab5 (show RAB5A Antibodies) and instead indicate that Rbpt5 is recruited by both Rabex5 (show RABGEF1 Antibodies) recognizing ubiquitylated cargo and by Rab4 to activate Rab5 (show RAB5A Antibodies) in a feed-forward manner.
Rab4 expression is up-regulated by laminar shear stress, which contributed to improved vascular endothelial cell autophagy and function.
Together the findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery.
HRES-1/Rab4 regulates autophagy through promoting the formation of LC3 (show MAP1LC3A Antibodies)(+) autophagosomes and the preservation of mitochondria.
Data indicate that Rab4 regulates ether-a-go-go-related (show KCNH2 Antibodies) gene (hERG (show KCNH2 Antibodies)) channel density via neural precursor cell-expressed developmentally down-regulated protein 4 (show NEDD4 Antibodies)-2 (Nedd4-2 (show NEDD4L Antibodies)).
our findings suggest an evolutionarily conserved function of HDPTP (show PTPN23 Antibodies)-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration.
TBC1D16 (show TBC1D16 Antibodies) is a GTPase activating protein (show RASA1 Antibodies) for Rab4A that regulates transferrin receptor recycling and EGFR (show EGFR Antibodies) trafficking and signaling.
Upregulated expression of rab4, rab5 (show RAB5A Antibodies), rab7 (show RAB7B Antibodies) and rab27 (show RAB27A Antibodies) correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.
Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.
Overexpression of Rab4 regulates angiotensin II type I receptor phosphorylation and sensitization.
Reduced Akt2 (show AKT2 Antibodies) leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (show PPARA Antibodies).
insulin (show INS Antibodies) signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 (show KIF3A Antibodies) with microtubules and this process is mediated by insulin (show INS Antibodies)-induced PI3-kinase (show PIK3CA Antibodies)-dependent PKC (show PKC Antibodies)-lambda activation and participates in GLUT4 (show SLC2A4 Antibodies) exocytosis
p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase (show RACGAP1 Antibodies) cycles of Rab5 (show RAB5A Antibodies) and Rab4
Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Sorting of PDGF (show PDGFA Antibodies) beta-receptors on early endosomes is regulated by sequential activation of PKCalpha (show PKCa Antibodies) and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.
Receptor recycling is mediated by AP-1 (show JUN Antibodies)/clathrin-coated vesicles and regulated by rab4 and rabaptin-5 (show RABEP1 Antibodies)/rabex-5 (show RABGEF1 Antibodies).
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
RAB4A, member RAS oncogene family
, ras-related protein Rab-4A
, Ras-related small GTP binding protein 4