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RAB6A encodes a member of the RAB family, which belongs to the small GTPase superfamily. Additionally we are shipping RAB6A, Member RAS Oncogene Family Antibodies (66) and many more products for this protein.
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Human RAB6A Protein expressed in Escherichia coli (E. coli) - ABIN667298
Burguete, Fenn, Brunger, Pfeffer: Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185. in Cell 2008
Show all 2 references for ABIN667298
Data show that basal body docking was unaffected in dynein 1 (dync1h1) mutation, but rab GTP-binding protein Rab6 expression was reduced.
Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions.
GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases.
several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6.
Data indicate that myosin Va (show MYO5A Proteins) interacted with multiple new Rab (show HRB Proteins) subfamilies including Rab6, Rab14 (show RAB14 Proteins) and Rab39B (show RAB39B Proteins).
Mint1 826 bridges APP (show APP Proteins) to the small GTPase (show RACGAP1 Proteins)
The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila.
Ric1-Rgp1 complex is a guanine nucleotide exchange factor (show RASGRF1 Proteins) for the late Golgi Rab6A GTPase (show RACGAP1 Proteins) and an effector of the medial Golgi Rab33B (show RAB33B Proteins) GTPase (show RACGAP1 Proteins).
GTP (show AK3 Proteins)-bound form of Rab6 promotes retrograde trafficking of cav-2 (show CAV2 Proteins) from the Golgi to ER
the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported.
The data reveal that Rab6a not only participates in modulating the organization of oocyte organelles, but also is a novel regulator of meiotic apparatus in mammalian oocytes.
Rab6a knockdown in oocytes may compromise the interaction between kinetochore and microtubule, which in turn leads to the activation of spindle assembly checkpoint signal, and, as a result, chromosome misalignment and spindle defects are established during meiosis, causing the production of aneuploid eggs and persistent defects in embryos.
Our study shows that RAB6 is an essential gene required for normal embryonic development
Rab6 GTPase (show RACGAP1 Proteins) was required during the phagosome maturation by its interaction with bicaudal-D1 (BICD1 (show BICD1 Proteins)) protein. Further data presented that the Rab6 GTPase (show RACGAP1 Proteins)-regulated phagocytosis could influence the proliferation of Staphylococcus aureus in macrophages.
Rab6a(Q72L) mediates LIS1 release from a LIS1-dynein complex followed by dynein activation
Rab6a/a' are important Golgi regulators of pro-inflammatory TNF (show TNF Proteins) secretion in macrophages.
Rab1 and Rab6 GTPases may play a role in modulating the function of retina by mediating the transport of nascent proteins along the early secretary pathway, particularly in the process of the light adaptation.
Rab6 recruits Rab6-interacting protein 1 on Golgi membranes.
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
RAB6A, member RAS oncogene family
, RAB6, member RAS oncogene family
, ras-related protein Rab-6A
, Ras-related protein Rab-6A
, Rab GTPase
, RAB6B, member RAS oncogene family