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Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Additionally we are shipping RAB7B Antibodies (38) and many more products for this protein.
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Authors determined the effects of T. suis soluble products (SPs (show SMS Proteins)) on Toll-like receptor-4 (TLR4 (show TLR4 Proteins))- In addition, T. suis SPs (show SMS Proteins) induce Rab7b, a negative regulator of TLR4 (show TLR4 Proteins) signalling
Rab9a (show RAB9A Proteins) and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex.
Rab7b is required for sortilin (show SORT1 Proteins) transport from endosomes to the TGN (show TG Proteins).
Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB (show NFKB1 Proteins) and promoting IL-6 (show IL6 Proteins) production.
Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity).
ras-related protein Rab-7b
, rab7B protein
, RAB7B, member RAS oncogene family
, Ras-related protein Rab-7