anti-RAD17 Homolog (S. Pombe) (RAD17) Antibodies

The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Additionally we are shipping RAD17 Homolog (S. Pombe) Kits (5) and RAD17 Homolog (S. Pombe) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAD17 5884 O75943
RAD17 19356 Q6NXW6
RAD17 310034  
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Top anti-RAD17 Homolog (S. Pombe) Antibodies at antibodies-online.com

Showing 10 out of 189 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RAD17 Antibody  Positive Control: Lane1: 25ug Hela lysate, Lane2: 25ug HEK293T lysate, Lane3: 25ug Xenopus laevis egg extract, Lane4: 25ug mouse embryonic stem cells lysate Primary Antibody Dilution :  1:500 Secondary Antibody :  Anti-rabbit-HRP  Secondry Antibody Dilution :  1:3000 Submitted by: Domenico Maiorano, Institute of Human Genetics, CNRS WB Suggested Anti-RAD17 Antibody Titration: 1.25ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysate RAD17 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RAD17 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Rad 17 expression in Lysates from  Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney (Lane 4). 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated FACS, WB RAD17 Antibody (Center) (ABIN655646) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the RAD17 antibody detected the RAD17 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of A549 cells using  RAD17 Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of RAD17 Antibody  in A549 cell line lysates (35ug/lane). This demonstrates the RAD17 antibody detected the RAD17 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated PLA, WB Western Blot: Rad17 Antibody [ABIN151740] - Whole cell lysate (30 ug) from HeLa cells before (-) or after (+) treatment with 10 Gy ionizing radiation. Antibody used at 0.1 ug/ml. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$775.50
Details
Human Rabbit Un-conjugated FACS, WB Western Blot: Rad17 Antibody [ABIN151253] - WB detection of RAD17 protein in human heart lysate using ABIN151253 at a dilution of 1:500 0.1 mg Log in to see 7 to 9 Days
$317.63
Details
Human Mouse Un-conjugated WB RAD17 monoclonal antibody (M01), clone 2G12 Western Blot analysis of RAD17 expression in HeLa NE. Detection limit for recombinant GST tagged RAD17 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated PLA, WB Western Blot analysis of human Phospho-Rad17 (Ser645), using ABIN151741. Western Blot: Rad17 [p Ser645] Antibody [ABIN151741] - Whole cell lysate (50 ug) from HeLa cells before (-) or after (+) treatment with 10 Gy ionizing radiation. Antibody used at 1 ug/ml. 100 μL Log in to see 7 to 9 Days
$538.13
Details

RAD17 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-RAD17 Homolog (S. Pombe) Antibodies

  1. Human Polyclonal RAD17 Primary Antibody for FACS, WB - ABIN151253 : Li, Peterson, Kanter-Smoler, Wei, Ramagli, Sunnerhagen, Siciliano, Legerski: hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. in Oncogene 1999 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal RAD17 Primary Antibody for ICC, IF - ABIN4349066 : Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal RAD17 Primary Antibody for PLA, WB - ABIN151740 : Jones, Colnaghi, Huang: Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability. in The EMBO journal 2012 (PubMed)

  4. Human Polyclonal RAD17 Primary Antibody for PLA, WB - ABIN151741 : Ge, Jackson, Blow: Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. in Genes & development 2007 (PubMed)

  5. Cow (Bovine) Polyclonal RAD17 Primary Antibody for WB - ABIN2779300 : Tsao, Geisen, Abraham: Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. in The EMBO journal 2004 (PubMed)

More Antibodies against RAD17 Homolog (S. Pombe) Interaction Partners

Arabidopsis thaliana RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.

Human RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. The Rad17 C-terminal tail is a molecular switch that regulates the 9-1-1 interaction and the ATR pathway.

  2. These data indicate that the interaction with the 9-1-1 complex is not required for Rad17 protein to be an efficient substrate for the UV-induced phosphorylation. Our data also raise the possibility that the 9-1-1 complex plays a negative regulatory role in the Rad17 phosphorylation. We also show that the nucleotide-binding activity of Rad17 is required for its nuclear localization.

  3. In a Japanese population, the variant allele of hRAD17 is significantly associated with a decreased risk of Colorectal Cancer among light smokers and rectal cancer patients and with an increased risk of Colorectal Cancer among heavy smokers.

  4. Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (show TP53 Antibodies) proteins.

  5. USP20 (show USP20 Antibodies) and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 (show USP20 Antibodies) regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 (show USP20 Antibodies) depletion results in poor activation of Chk1 (show CHEK1 Antibodies) protein by phosphorylation

  6. These data suggest that v-Src (show SRC Antibodies) attenuates ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) signaling through the inhibition of Rad17-Rad9 (show RAD9A Antibodies) interaction.

  7. Rad17 is phosphorylated by ATM (show ATM Antibodies) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (show NBN Antibodies), facilitating recruitment of MRE11 (show MRE11A Antibodies), RAD50 (show RAD50 Antibodies) and ATM (show ATM Antibodies) to the DNA double-strand breaks.

  8. Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (show CHEK1 Antibodies).

  9. Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (show CHEK1 Antibodies) phosphorylation and substantial RPA32 (show RPA2 Antibodies) Ser33 phosphorylation.

  10. Data indicate that regulation of Rad17 turnover is through the Cdh1 (show CDH1 Antibodies)/anaphase-promoting complex pathway in breast cancer cells.

Mouse (Murine) RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation

RAD17 Homolog (S. Pombe) (RAD17) Antigen Profile

Protein Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Gene names and symbols associated with RAD17

  • RAD17 homolog (S. pombe) (RAD17) antibody
  • RAD17 homolog (S. pombe) (rad17) antibody
  • Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins (RAD17) antibody
  • cell cycle checkpoint protein RAD17 (ATRAD17) antibody
  • RAD17 homolog (S. pombe) (Rad17) antibody
  • 9430035O09Rik antibody
  • CCYC antibody
  • HRAD17 antibody
  • K2A18.21 antibody
  • K2A18_21 antibody
  • MmRad24 antibody
  • R24L antibody
  • RAD17 antibody
  • RAD17SP antibody
  • RAD24 antibody
  • RADIATION SENSITIVE 17 antibody
  • zgc:91969 antibody

Protein level used designations for RAD17

RAD17 homolog (S. pombe) , cell cycle checkpoint protein RAD17-like , cell cycle checkpoint protein RAD17 , Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins , Rad17p , RAD17 homolog , Cell cycle checkpoint protein RAD17 , RAD1 homolog , RF-C activator 1 homolog , RF-C/activator 1 homolog , Rad17-like protein , cell cycle checkpoint protein (RAD17)

GENE ID SPECIES
100081629 Ornithorhynchus anatinus
100339735 Oryctolagus cuniculus
100385537 Callithrix jacchus
100464145 Ailuropoda melanoleuca
436934 Danio rerio
854550 Saccharomyces cerevisiae S288c
100190842 Pongo abelii
836745 Arabidopsis thaliana
5884 Homo sapiens
19356 Mus musculus
478088 Canis lupus familiaris
513600 Bos taurus
310034 Rattus norvegicus
100065769 Equus caballus
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