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RAD18 Homolog (S. Cerevisiae) Proteins (RAD18)

The protein encoded by RAD18 is highly similar to S. Additionally we are shipping RAD18 Antibodies (71) and RAD18 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAD18 56852 Q9NS91
RAD18 58186 Q9QXK2
Rat RAD18 RAD18 362412  
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Top RAD18 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RAD18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for RAD18 Homolog (S. Cerevisiae) (RAD18) Interaction Partners

Human RAD18 Homolog (S. Cerevisiae) (RAD18) interaction partners

  1. USP7 (show USP7 Proteins)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway

  2. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  3. Significantly restored tolerance of RAD18-/- and RNF8 (show RNF8 Proteins)-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Proteins) focus formation.

  4. these results suggest that miR (show MLXIP Proteins)-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.

  5. We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin (show UBB Proteins) chains by small-angle X-ray scattering and derived a structural model for the complex.

  6. Rad18 protein ubiquitin-binding zinc fingers domain has alpha-helix and strand beta1 conformation.

  7. Monoubiquitination has a role in controlling Rad18 function.

  8. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

  9. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway.

  10. Findings indicate that RAD18 may serve as a key mediator of the ionizing radiation (IR)response and may function as a potential target for circumventing IR resistance in glioblastoma multiforme (GBM).

Mouse (Murine) RAD18 Homolog (S. Cerevisiae) (RAD18) interaction partners

  1. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  2. RAD18 contributes to maintenance of genomic stability through postreplication repair

  3. Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase

  4. Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.

  5. RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.

RAD18 Protein Profile

Protein Summary

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Gene names and symbols associated with RAD18

  • RAD18 homolog (S. cerevisiae) (rad18)
  • RAD18 homolog (S. cerevisiae) (RAD18)
  • similar to postreplication repair protein hRAD18p (RAD18)
  • E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair (RAD18)
  • similar to S. cerevisiae RAD18 (YCR066W) ubiquitin conjugating enzyme involved in DNA repair, Zn finger protein; same as cosmid orf Ca20C1.14c (RAD18)
  • DNA repair protein and ATPase (RAD18)
  • C3HC4-type zinc finger-containing protein (rad18)
  • RAD18 homolog (S. cerevisiae) (Rad18)
  • 2810024C04Rik protein
  • DDBDRAFT_0218120 protein
  • DDBDRAFT_0304878 protein
  • DDB_0218120 protein
  • DDB_0304878 protein
  • DKFZp469H0810 protein
  • RAD18 protein
  • Rad18sc protein
  • RNF73 protein
  • zgc:55577 protein

Protein level used designations for RAD18

E3 ubiquitin-protein ligase RAD18 , RAD18 homolog (S. cerevisiae) , postreplication repair protein hRAD18p , similar to postreplication repair protein hRAD18p , E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair , Rad18p , hypothetical protein , DNA repair protein and ATPase , SAP DNA-binding domain-containing protein , RAD18 homolog , E3 ubiquitin-protein ligase RAD18-like , e3 ubiquitin-protein ligase RAD18-like , RAD18, S. cerevisiae, homolog , RING finger protein 73 , hHR18 , hRAD18 , postreplication repair protein RAD18 , RAD18-like protein , mRAD18Sc , post-replication repair protein RAD18SC

GENE ID SPECIES
393106 Danio rerio
460144 Pan troglodytes
704708 Macaca mulatta
850430 Saccharomyces cerevisiae S288c
3641637 Candida albicans SC5314
3641662 Candida albicans SC5314
4839641 Scheffersomyces stipitis CBS 6054
8621702 Dictyostelium discoideum AX4
100052645 Equus caballus
100172537 Pongo abelii
100395032 Callithrix jacchus
100473633 Ailuropoda melanoleuca
100591424 Nomascus leucogenys
56852 Homo sapiens
416114 Gallus gallus
476544 Canis lupus familiaris
100217383 Sus scrofa
514440 Bos taurus
58186 Mus musculus
362412 Rattus norvegicus
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