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The protein encoded by RAD18 is highly similar to S. Additionally we are shipping RAD18 Proteins (6) and RAD18 Kits (1) and many more products for this protein.
Showing 10 out of 104 products:
Human Monoclonal RAD18 Primary Antibody for IF, IHC (p) - ABIN566046
Hicks, Chute, Paulsen, Ragland, Howlett, Guéranger, Glover, Canman: Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. in Molecular and cellular biology 2010
Show all 7 Pubmed References
Mouse (Murine) Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452085
Sun, Yomogida, Sakao, Yamamoto, Yoshida, Watanabe, Morita, Araki, Yamamura, Tateishi: Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. in Mechanisms of development 2009
Show all 4 Pubmed References
Human Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452086
Tateishi, Sakuraba, Masuyama, Inoue, Yamaizumi: Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 3 Pubmed References
Human Polyclonal RAD18 Primary Antibody for IP, PLA - ABIN253202
Williams, Longerich, Sung, Vaziri, Kupfer: The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. in Blood 2011
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Human Monoclonal RAD18 Primary Antibody for WB - ABIN252484
Lyakhovich, Shekhar: Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. in Molecular and cellular biology 2003
Show all 2 Pubmed References
Human Polyclonal RAD18 Primary Antibody for IP - ABIN253201
Wagner, Karnitz: Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. in Molecular pharmacology 2009
Cow (Bovine) Polyclonal RAD18 Primary Antibody for WB - ABIN2774765
Tsuji, Watanabe, Araki, Shinohara, Yamagata, Tsurimoto, Hanaoka, Yamamura, Yamaizumi, Tateishi: Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. in Genes to cells : devoted to molecular & cellular mechanisms 2008
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R (show IGF1R Antibodies) interacts with and phosphorylates PCNA (show PCNA Antibodies) at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA (show PCNA Antibodies) by RAD18 and SHPRH (show SHPRH Antibodies). (IGF1R (show IGF1R Antibodies) = insulin-like growth factor 1 receptor (show IGF1R Antibodies); PCNA (show PCNA Antibodies) = proliferating cell nuclear antigen (show PCNA Antibodies); RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH (show SHPRH Antibodies) = E3 ubiquitin-protein ligase SHPRH (show SHPRH Antibodies))
Ubiquitin ligases RNF168 (show RNF168 Antibodies), RNF169 (show RNF169 Antibodies), and RAD18 specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (show TP53BP1 Antibodies) chromatin recruitment may be activated by RNF168 (show RNF168 Antibodies) and blocked by RNF169 (show RNF169 Antibodies) and RAD18.
WRNIP1 (show WRNIP1 Antibodies) connects PCNA (show PCNA Antibodies) monoubiquitination with ATMIN (show ATMIN Antibodies)/ATM (show ATM Antibodies) to activate ATM (show ATM Antibodies) signalling in response to replication stress and contribute to the maintenance of genomic stability.
RAD18 polymorphisms are correlated with the side effects of platinum-chemotherapy in Chinese patients with advanced NSCLC.
REV1 (show REV1 Antibodies) can promote (show PCNA Antibodies)PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
USP7 (show USP7 Antibodies)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway
RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.
Significantly restored tolerance of RAD18-/- and RNF8 (show RNF8 Antibodies)-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Antibodies) focus formation.
these results suggest that miR (show MLXIP Antibodies)-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.
We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin (show UBB Antibodies) chains by small-angle X-ray scattering and derived a structural model for the complex.
Somatic hypermutation of immunoglobulin genes (SHM (show CNTNAP1 Antibodies)) in Rad18 KO mice was similar to wild-type mice, suggesting that Rad18 is dispensable for SHM (show CNTNAP1 Antibodies).
Rad18 confers DNA damage tolerance and tumor-suppression in a physiological setting.
REV1 promote PCNA (show PCNA Antibodies) monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
RAD18 contributes to maintenance of genomic stability through postreplication repair
Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase
Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.
RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
E3 ubiquitin-protein ligase RAD18
, RAD18, S. cerevisiae, homolog
, RING finger protein 73
, postreplication repair protein RAD18
, postreplication repair protein hRAD18p
, post-replication repair protein RAD18SC
, RAD18 homolog (S. cerevisiae)
, similar to postreplication repair protein hRAD18p
, E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
, hypothetical protein
, DNA repair protein and ATPase
, SAP DNA-binding domain-containing protein
, RAD18 homolog
, RAD18-like protein
, E3 ubiquitin-protein ligase RAD18-like
, e3 ubiquitin-protein ligase RAD18-like